NEUTRAL 2-LOCUS MULTIPLE ALLELE MODELS WITH RECOMBINATION
NEUTRAL 2-LOCUS MULTIPLE ALLELE MODELS WITH RECOMBINATION
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DOI：
10.1016/0040-5809(81)90016-2
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发表时间：
1981-01-01
影响因子：
1.4
通讯作者：
GRIFFITHS, RC
中科院分区：
文献类型：
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作者：
GRIFFITHS, RC
对于中性、平稳、2位点多等位基因模型，推导出连锁不平衡的纯合性和方差的一般公式，其中每个位点都有对称型突变。研究的特殊案例有K等位基因模型、无限等位基因模型和逐步突变模型。在分子水平上检验了2位点无限等位基因模型，并在随机选择的2个配子中找到了每个位点杂合位点数量的联合概率生成函数。
General formulae for the homozygosity and variance of linkage disequilibrium are derived for neutral, stationary, 2-locus multiple allele models where there is a symmetric type of mutation at each locus. Particular cases examined are K allele models, the infinite alleles model and the stepwise mutation model. The 2 locus infinite allele model is examined at the molecular level and a joint probability generating function is found for the number of heterozygous sites at each locus in 2 randomly chosen gametes.