SUPPRESSION OF NEURITE ELONGATION AND GROWTH CONE MOTILITY BY ELECTRICAL-ACTIVITY
SUPPRESSION OF NEURITE ELONGATION AND GROWTH CONE MOTILITY BY ELECTRICAL-ACTIVITY
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DOI：
10.1126/science.3715470
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发表时间：
1986-06-27
期刊：
影响因子：
56.9
通讯作者：
KATER, SB
中科院分区：
文献类型：
--
作者：
COHAN, CS;KATER, SB
电活动除了其在沿沿着神经细胞传递信号中的作用之外，还可以调节许多神经元功能。通过刺激细胞培养物中分离的单个蜗牛神经元来测试电活动影响出芽神经元中神经突伸长的假设。研究结果表明，生长锥的进步，从而轴突伸长，可逆地停止期间，当动作电位实验诱发。还观察到丝状伪足数目和生长锥面积减少。因此，动作电位可以介导神经突生长的停止，从而可以影响神经系统内的结构和连接。
Electrical activity may regulate a number of neuronal functions in addition to its role in transmitting signals along nerve cells. The hypothesis that electrical activity affects neurite elongation in sprouting neurons was tested by stimulating individual snail neurons isolated in cell culture. The findings demonstrated that growth cone advance, and thus neurite elongation, is reversibly stopped during periods when action potentials are experimentally evoked. A decrease in filopodial number and growth cone area was also observed. Thus, action potentials can mediate the cessation of neurite outgrowth and thereby may influence structure and connectivity within the nervous system.