REGULATION OF SYNAPTIC STRENGTH BY SPHINGOSINE 1-PHOSPHATE IN THE HIPPOCAMPUS
REGULATION OF SYNAPTIC STRENGTH BY SPHINGOSINE 1-PHOSPHATE IN THE HIPPOCAMPUS
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DOI：
10.1016/j.neuroscience.2010.10.021
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发表时间：
2010-12-29
期刊：
影响因子：
3.3
通讯作者：
Nakamura, S.
中科院分区：
文献类型：
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作者：
Kanno, T.;Nishizaki, T.;Nakamura, S.
虽然海马体是一个与短期记忆有关的大脑区域，记忆形成的分子机制尚不完全清楚，本研究表明，sphingosine 1 phosphate （SIP）在记忆形成中起着关键作用，在大鼠海马片中添加SIP可增加海马CA3区记录的AMPA受体介导的微型兴奋性突触后电流（mEPSCs）的速率，此外，在CA3区观察到的长期增强（LTP）可被SphK抑制剂有效抑制这种抑制作用被SIP完全逆转，在SphK1敲除小鼠的海马切片中，特别是在CA3区域，LIP受损。这些结果有力地表明，SphK/S1P受体信号在海马CA3区的兴奋性突触传递中起着重要作用，并对海马的空间学习等功能产生深远影响(C) 2010 IBRO出版，Elsevier Ltd所有权利保留
Although the hippocampus is a brain region involved in short term memory, the molecular mechanisms underlying memory formation are not completely under stood Here we show that sphingosine 1 phosphate (SIP) plays a pivotal role in the formation of memory Addition of SIP to rat hippocampal slices increased the rate of AMPA receptor mediated miniature excitatory postsynaptic cur rents (mEPSCs) recorded from the CA3 region of the hippocampus In addition long term potentiation (LTP) observed in the CA3 region was potently inhibited by a sphingosine kinase (SphK) inhibitor and this inhibition was fully reversed by SIP LIP was impaired in hippocampal slices specifically in the CA3 region obtained from SphK1 knockout mice, which correlates well with the poor performance of these animals in the Morris water maze test These results strongly suggest that SphK/S1P receptor signaling plays an important role in excitatory synaptic transmission in the CA3 region of hippocampus and has profound effects on hippocampal function such as spatial learning (C) 2010 IBRO Published by Elsevier Ltd All rights reserved