CARDIAC-OUTPUT AND UTEROPLACENTAL BLOOD-FLOW IN DIET-RESTRICTED AND DIET-REPLETED PREGNANT RATS
CARDIAC-OUTPUT AND UTEROPLACENTAL BLOOD-FLOW IN DIET-RESTRICTED AND DIET-REPLETED PREGNANT RATS
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DOI：
10.1016/0002-9378(83)90918-3
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发表时间：
1983-01-01
影响因子：
9.8
通讯作者：
LIPSHITZ, J
中科院分区：
文献类型：
--
作者：
AHOKAS, RA;ANDERSON, GD;LIPSHITZ, J
用15.MU测量心输出量和子宫胎盘血流量。麻醉孕鼠随机喂养放射性微球，妊娠第5天开始限食50%，第5~13天限食5%，第14天临时限食。另一组未怀孕的大鼠也被随机喂养。饮食限制导致孕妇体重净减少，到怀孕第21天时平均胎儿体重和平均胎盘重量减少了20%。在妊娠的最后一周，自由喂养的限制性母体显示出母亲的净体重增加，而平均胎儿体重，但不包括胎盘重量，接近于临时喂养的对照组。在饮食限制的大鼠中，怀孕20天和21天时，与对照组相比，总心输出量减少了30%，但单位母亲体重的心输出量没有显著差异。饮食限制减少了子宫和胎盘的总血流量。65%。妊娠晚期的饮食补充并没有显著增加总的心输出量或单位体重的心输出量。子宫和胎盘的总血流量接近对照组，主要是因为心输出量分配到子宫的比例增加。
Cardiac output and uteroplacental blood flow were measured with 15 .mu. radioactive microspheres in anesthetized pregnant rats which were fed: ad lib throughout gestation; a 50% restricted diet from day 5 of gestation and a 5% restricted diet from days 5-13 of gestation and ad lib from day 14 of gestation. An additional group of nonpregnant rats fed ad lib was also used. Dietary restriction caused a net maternal weight loss and a 20% reduction in mean fetal weight and mean placental weight by day 21 of gestation. Restricted dams fed ad lib during the last week of gestation showed a net maternal weight gain, while mean fetal weight, but not placental weight, was near that of the ad lib-fed controls. In the diet-restricted rats, total cardiac output was reduced 30% relative to controls by days 20 and 21 of gestation, but cardiac output per unit maternal body weight was not significantly different. Dietary restriction decreased both total uterine and placental blood flow by .apprx. 65%. Diet repletion late in gestation did not significantly increase total cardiac output or cardiac output per unit body weight. Total uterine and placental blood flows were near those of controls, primarily because of an increased fraction of cardiac output distributed to the uterus.