Effects of aging, diet, and sex on plasma glucose, fructosamine, and lipid concentrations in barrier-raised Fischer 344 rats.
Effects of aging, diet, and sex on plasma glucose, fructosamine, and lipid concentrations in barrier-raised Fischer 344 rats.
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衰老、饮食和性别对屏障饲养的 Fischer 344 大鼠血浆葡萄糖、果糖胺和脂质浓度的影响。
DOI：
10.1093/geronj/48.5.b184
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Kumar,D
中科院分区：
文献类型：
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作者：
VanLiew,JB;Davis,PJ;Davis,FB;Bernardis,LL;Deziel,MR;Marinucci,LN;Kumar,D
我们研究了血糖，果糖胺，甘油三酯和胆固醇的关系，作为年龄，性别和饮食的功能，在屏障饲养的Fischer 344大鼠年龄5至26个月，喂养的饮食无论是随意或限制到60%的随意热量摄入。这些血浆水平与年龄、性别和饮食的复杂关系导致开发了以年龄、饮食和性别为协变量的模型。总体而言，与自由进食动物相比，限制饮食大鼠的空腹血糖浓度降低约25%。雄性动物的血糖水平呈显著的年龄依赖性下降，而雌性动物的血糖水平则随年龄增长而升高。总体而言，热量限制动物的血浆果糖胺水平与自由进食动物的水平相比降低了7%。血浆葡萄糖和果糖胺水平之间存在显著正相关。与自由进食动物相比，热量限制大鼠的平均血浆甘油三酯含量降低了50%。在雄性动物中观察到甘油三酯水平随年龄增加而显著降低，在雌性动物中观察到甘油三酯水平随年龄增加而升高。血糖和甘油三酯水平之间存在显著正相关。与自由进食动物的水平相比，热量限制动物的血浆胆固醇水平降低了7%。随着年龄的增长，胆固醇浓度的增加是显着的男性和女性。对数据的分析表明，雄性和雌性Fischer 344大鼠的血糖和果糖胺对衰老和热量限制的反应存在显著差异。血浆甘油三酯和胆固醇随增龄和饮食热量限制的变化也存在性别差异。研究衰老对血脂和血脂含量的影响应考虑动物性别的贡献。
We studied the relationships of plasma glucose, fructosamine, triglycerides, and cholesterol as a function of age, gender, and diet in barrier-raised Fischer 344 rats aged 5 to 26 months, fed a diet either ad libitum or restricted to 60% of the ad libitum caloric intake. The complex relationships of these plasma levels to age, gender, and diet led to the development of a model with age, diet, and sex as covariates. Overall, fasting plasma glucose concentrations were reduced by approximately 25% in rats on the restricted diet, compared to ad libitum-fed animals. There was a significant age-dependent decline in glucose levels in male animals, whereas in females there was an increase in plasma glucose with aging. Plasma fructosamine levels in calorie-restricted animals, overall, were reduced by 7% compared to levels in animals fed ad libitum. There was a significant positive correlation between plasma glucose and fructosamine levels. Mean plasma triglyceride content was decreased by 50% in calorie-restricted rats compared to ad libitum-fed animals. A significant decrease in triglyceride levels with increasing age was seen in male animals, and an increase with aging in females. There was a significant positive correlation between plasma glucose and triglyceride levels. Plasma cholesterol levels in calorie-restricted animals were reduced by 7% compared to levels in ad libitum-fed animals. An increase of cholesterol concentration with aging was significant in both males and females. Analysis of the data showed that there were significant differences between male and female Fischer 344 rats in the response of plasma glucose and fructosamine to aging and calorie restriction. Changes of plasma triglyceride and cholesterol with aging and dietary calorie restriction were also different in males and females. Studies of the effect of aging on glycemia and blood lipid content should take into account the contributions of animal sex.