Analysis of the effectiveness of contromeasures against Schistosoma mekongi using an intra- and inter-village model inChampasak Province
Analysis of the effectiveness of contromeasures against Schistosoma mekongi using an intra- and inter-village model inChampasak Province
复制标题
利用占巴塞省村内和村间模型分析湄公血吸虫防治措施的有效性
DOI：
10.1016/j.parint.2011.07.017
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Ishikawa H
中科院分区：
文献类型：
--
作者：
Fukuhara K;Phompida S;Insisiengm S;Kirinoki M;Chigusa Y;Nakamura S;Matsuda H;Ishikawa H
湄公河血吸虫病在老挝人民民主共和国的Khong地区流行，该地区由湄公河中的一个大岛Khong和许多小岛组成。湄公河血吸虫是由开放新锥虫作为中间宿主沿着湄公河传播的。因此，即使S.如果湄公河上游的某个村庄被消灭了，那么如果感染源是湄公河上游的一个村庄，感染可能会复发。本研究的目的是建立一个数学模型的传播S。本模型的主要特点是考虑到尾蚴和毛蚴寿命的缩短和在湄公河中的扩散，具有处理湄公河流域村庄间传染病扩散的能力。该模型还考虑了湄公河水位的季节性波动，这影响了人类与水接触的行为。模拟的结果表明，当普遍的大规模治疗在更上游的村庄同时进行时，湄公血吸虫病的流行率将被抑制在较低的水平，在一个更下游的村庄很长一段时间。
Schistosomiasis mekongi is prevalent in the Khong district of Lao PDR, made up of one big island, Khong, and numerous small islands in the Mekong River. Schistosoma mekongi is spread by Neotricula aperta as the intermediate host along the Mekong River. Therefore, even if an epidemic of S. mekongi were stamped out in a certain village, infection may recur if the source of infection is a village located in the upper reaches of the Mekong River. The purpose of this study was to construct a mathematical model for the transmission of S. mekongi among villages from the upper to lower Mekong River to estimate the effect of control measures against it. The chief characteristic of the present model is competence in dealing with the spread of infection among villages through the Mekong River in consideration of the reduction in longevity of cercariae and miracidia and their diffusion in the river. The model also takes into account seasonal fluctuation in the water level of the Mekong River, which affects human behavior in terms of water contact. The results of simulations indicated that the prevalence of schistosomiasis mekongi would be suppressed to a low level for a long time in a village further downstream when universal mass treatment is performed in villages further upstream simultaneously.