Prefrontal Cortex Deep Brain Stimulation Improves Fear and Anxiety-Like Behavior and Reduces Basolateral Amygdala Activity in a Preclinical Model of Posttraumatic Stress Disorder
Prefrontal Cortex Deep Brain Stimulation Improves Fear and Anxiety-Like Behavior and Reduces Basolateral Amygdala Activity in a Preclinical Model of Posttraumatic Stress Disorder
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DOI：
10.1038/npp.2017.207
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发表时间：
2018-04-01
影响因子：
7.6
通讯作者：
Hamani, Clement
中科院分区：
文献类型：
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作者：
Reznikov, Roman;Bambico, Francis Rodriguez;Hamani, Clement
深部脑刺激 (DBS) 正在研究用于治疗多种精神疾病，包括创伤后应激障碍 (PTSD)。临床前研究仍然是开发新 DBS 应用的基石。我们研究了将 DBS 传递到边缘下皮层（IL）（参与应激恢复机制的区域）是否可以对抗大鼠的行为异常，这些行为异常在暴露于恐惧调节后表现出持续的消退缺陷和长期焦虑。经历恐惧调节/消退的大鼠被分为弱消退组和强消退组（WE > 70% 或 SE
Deep brain stimulation (DBS) is being investigated for a number of psychiatric indications, including posttraumatic stress disorder (PTSD). Preclinical studies continue to be a cornerstone for the development of new DBS applications. We investigate whether DBS delivered to the infralimbic cortex (IL), a region involved in mechanisms of stress resiliency, may counter behavioral abnormalities in rats that present persistent extinction deficits and long-term anxiety after exposure to fear conditioning. Rats undergoing fear conditioning/extinction were segregated into weak and strong extinction groups (WE >70% or SE