Adults with sickle cell disease may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study
Adults with sickle cell disease may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study
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DOI：
10.1111/jan.12755
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发表时间：
2016-06-01
影响因子：
3.8
通讯作者：
Jonassaint, Charles R.
中科院分区：
文献类型：
--
作者：
Crawford, Regina D.;Jonassaint, Charles R.
目标。本研究的目的：（1）使用计算机神经心理学测试评估患有镰状细胞病的成年人的认知功能;（2）复制先前确定的镰状细胞病患者和对照组之间的处理速度差异。先前的证据表明，与对照组相比，镰状细胞病成年患者在大多数领域的认知功能较差，但最显着的缺陷似乎是在处理速度方面。2008年6月至2010年6月进行横断面病例对照研究。采用计算机化、自我管理的神经心理学测试对31名镰状细胞病患者和17名年龄、性别和种族相匹配的对照者的认知功能进行了测量。评估平均30分钟，并记录了7个计算机化测试的分数：语言和视觉记忆，手指敲击，符号数字编码，Stroop测试，转移注意力和持续性能。镰状细胞病患者的CNS生命体征处理速度域得分比对照组低10.76分。虽然不显著，但患者在全指数上的得分比对照组低5.73分，但在调整处理速度后，患者的平均得分比对照组高3分。执行功能和注意力的差异并不显着，记忆没有组间差异。使用一个简短的，计算机管理的30分钟神经心理学测试，我们能够复制以前的研究结果，显示镰状细胞病患者的处理速度超过10分的缺陷。当考虑到处理速度的差异时，患者在认知任务上的表现与对照组一样好或更好。
Aims. This study aimed to: (1) evaluate cognitive function among adults with sickle cell disease using a computer-administered neuropsychological test; and (2) replicate previously identified differences in processing speed between patients with sickle cell disease and controls.Background. Previous evidence suggests that, compared with controls, adult patients with sickle cell disease have poorer cognitive functioning across most domains but the most significant deficits appear to be in the area of processing speed.Design. Cross-sectional case-control study conducted from June 2008-June 2010.Methods. Cognitive functioning was measured using computerized, self-administered, neuropsychological tests among 31 patients with sickle cell disease and 17 controls matched for age, gender and race. The assessment averaged 30 minutes and scores were recorded for seven computerized tests: verbal and visual memory, finger tapping, symbol digit coding, Stroop test, shifting attention and continuous performance.Results. Patients with sickle cell disease scored 10.76 points lower on the CNS Vital Signs processing speed domain than controls. Although non-significant, patients scored 5.73 points lower on the full index than controls but after adjusting for processing speed, mean scores for patients were 3 points greater compared with controls. Differences in executive functioning and attention were not significant and memory did not differ between groups.Conclusion. Using a brief, computer-administered 30-minute neuropsychological test, we were able to replicate previous findings showing a greater than 10-point deficit in processing speed among patients with sickle cell disease. When differences in processing speed are taken into account, patients perform equally well or better than controls on cognitive tasks.