Administration of progesterone to cows with ovarian follicular cysts results in a reduction in mean LH and LH pulse frequency and initiates ovulatory follicular growth.
Administration of progesterone to cows with ovarian follicular cysts results in a reduction in mean LH and LH pulse frequency and initiates ovulatory follicular growth.
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对患有卵巢滤泡囊肿的奶牛施用黄体酮会导致平均 LH 和 LH 脉冲频率降低，并启动排卵卵泡生长。
DOI：
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发表时间：
1999
影响因子：
3.3
通讯作者：
H. Garverick
中科院分区：
文献类型：
--
作者：
M. Calder;B. E. Salfen;B. Bao;R. S. Youngquist;H. Garverick
用孕酮治疗患有卵巢卵泡囊肿的奶牛，以确定是否会发生LH浓度降低和排卵卵泡波启动。当单个卵泡结构> 20 mm或多个结构直径> 15 mm在低孕酮浓度存在下存在7 d时，使用经直肠超声诊断囊肿。研究了三组：1）具有正常发情周期的奶牛（CYC，n = 8）; 2）具有未处理的囊肿的奶牛（CYST，n = 7）;和3）具有用两种孕酮释放阴道内装置处理9天的囊肿的奶牛（PRID，n = 8）。经直肠超声检查卵巢，每天采集血样分析孕酮和FSH。在第0天（仅限CYST和PRID奶牛）、第1、5、9和10天采集用于测定平均LH和LH脉冲频率的系列血样。在整个PRID治疗期间，PRID奶牛中的孕酮浓度高于CYST奶牛（P < .002）。第0天，PRID（6.6+/-.6脉冲/8 h）和CYST奶牛（5.1+/-.6脉冲/8 h）的LH脉冲频率相似（P = .10），但第0天PRID奶牛（2.5+/-.2 ng/mL）的平均LH往往高于（P = .054）CYST奶牛（1.9+/-.2 ng/mL）。与CYST奶牛（2.1 +/-.2 ng/mL，5.6+/-.6脉冲/8 h）相比，PRID奶牛（1.1 +/-.2 ng/mL，1.8+/-.6脉冲/8 h）的平均LH和LH脉冲频率在第1天降低（P < .002），并在整个实验期间保持较低水平。在第3天和第4天，PRID奶牛的FSH浓度高于CYC和CYST奶牛（P <0.01）。FSH浓度的增加先于PRID诱导的卵泡波的出现。在PRID治疗期间，所有PRID奶牛和7头CYST奶牛中的4头启动了新的卵泡波。CYST奶牛（d 5.2+/-1.7）和PRID奶牛（d 5.5+/-0.6）的卵泡波启动晚于CYC奶牛（d 1.8+/-0.3）（P <0.05）。与CYST奶牛相比，PRID奶牛在给药期结束时的囊肿较小（P <0.01）。没有CYST奶牛排卵，但所有PRID奶牛排卵后3或4天PRID去除新开发的卵泡。外源性孕酮治疗降低了囊肿奶牛的LH，随后是正常排卵卵泡的发育。
Cows with ovarian follicular cysts were treated with progesterone to determine whether a reduction in LH concentrations and initiation of ovulatory follicular waves would occur. Cysts were diagnosed using transrectal ultrasonography when single follicular structures > 20 mm or multiple structures > 15 mm in diameter were present for 7 d in the presence of low progesterone concentrations. Three groups were studied: 1) cows with normal estrous cycles (CYC, n = 8); 2) cows with untreated cysts (CYST, n = 7); and 3) cows with cysts treated with two progesterone-releasing intravaginal devices (PRID, n = 8) for 9 d. Ovaries were examined with transrectal ultrasonography, and blood samples were collected daily for analysis of progesterone and FSH. Serial blood samples for determination of mean LH and LH pulse frequency were collected on d 0 (CYST and PRID cows only), 1, 5, 9, and 10. Progesterone concentrations were higher in PRID cows than in CYST cows throughout the PRID treatment period (P < .002). On d 0, LH pulse frequency was similar (P = .10) in PRID (6.6+/-.6 pulses/8 h) and CYST cows (5.1+/-.6 pulses/8 h), but mean LH tended to be higher (P = .054) on d 0 in PRID cows (2.5+/-.2 ng/mL) than in CYST cows (1.9+/-.2 ng/mL). Mean LH and LH pulse frequency decreased (P < .002) by d 1 in PRID cows (1.1+/-.2 ng/mL, 1.8+/-.6 pulses/8 h) compared with CYST cows (2.1+/-.2 ng/mL, 5.6+/-.6 pulses/8 h) and remained lower throughout most of the experimental period. The FSH concentrations were higher (P < .01) in PRID cows than in CYC and CYST cows on d 3 and 4. The increase in FSH concentrations preceded emergence of the PRID-induced follicular wave. All PRID cows and four of seven CYST cows initiated new follicular waves during the period of PRID treatment. Follicular waves were initiated later (P < .05) in CYST cows (d 5.2+/-1.7) and PRID cows (d 5.5+/-.6) than in CYC cows (d 1.8+/-.3). Cysts were smaller (P < .01) at the end of the treatment period in PRID cows compared with CYST cows. No CYST cows ovulated, but all PRID cows ovulated newly developed follicles 3 or 4 d after PRID removal. Treatment with exogenous progesterone reduced LH in cows with cysts, and this was followed by development of normal ovulatory follicles.
影响因子：
3.6
作者：
FORTUNE, JE;VINCENT, SE
通讯作者：
VINCENT, SE
有证据表明，下丘脑内侧基底节是雌二醇诱导母羊排卵前促性腺激素释放激素激增的主要作用部位。
DOI：
10.1210/endo.139.4.5904
发表时间：
1998
期刊：
Endocrinology.
影响因子：
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作者：
Caraty,A;Fabre-Nys,C;Delaleu,B;Locatelli,A;Bruneau,G;Karsch,FJ;Herbison,A
通讯作者：
Herbison,A