Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI
Detection of age-dependent changes in healthy adult lungs with diffusion-weighted 3He MRI
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DOI：
10.1016/j.acra.2005.08.005
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发表时间：
2005-11-01
影响因子：
4.8
通讯作者：
Owers-Bradley, J
中科院分区：
文献类型：
--
作者：
Fain, SB;Altes, TA;Owers-Bradley, J
理由和目标。采用扩散加权He-3 MRI研究无吸烟史的健康成人受试者肺微结构的变化。应用超极化氦3（He-3）的扩散磁共振成像对健康志愿者进行研究，以探讨肺微结构变化随年龄的依赖性，反映在肺气隙中He-3的表观扩散系数（ADC）的变化。将来自三个研究中心（弗吉尼亚大学（UVa），N = 25;威斯康星州（UW），N = 8;诺丁汉大学（UN），N = 11）的数据合并在汇总分析中，共包括N = 44例受试者（年龄范围，18-69岁;平均年龄，41.7 ± 16.7岁）。在所有三个部位发现ADC依赖于年龄（UW，R =+0.95，P = 0.0003; UVa，R =+0.74，P <0.0001; UN R =+0.96，P <0.0001）。各研究中心平均ADC随年龄的增加相似（UW，+0.0017 cm（2）s（-1）y（-1）; UVa。+0.0015 cm（2）s（-1）y（-1）;合并，+0.0015 cm（2）s（-1）y（-1）; P = .71）。在对UW数据进行的区域分析中，ADC的增加影响了肺的所有区域，但与肺底相比，肺顶和中部区域显示出更大的增加。结果表明，所观察到的ADC的年龄依赖性可能是由于肺微观结构的变化，增加肺泡体积在老化过程中。
Rationale and Objectives. To investigate changes in lung microstructure in healthy adult subjects with no smoking history using diffusion-weighted He-3 MRI.Materials and Methods. Diffusion magnetic resonance imaging using hyperpolarized helium 3 (He-3) was applied to healthy volunteers to explore the dependence of lung microstructural changes with age, reflected by changes in the apparent diffusion coefficient (ADC) of He-3 in lung air spaces. Data from three sites (University of Virginia (UVa), N = 25; University of Wisconsin (UW), N = 8; University of Nottingham (UN), N = 11) were combined in pooled analysis, including a total of N = 44 subjects (age range, 18-69 years; average age, 41.7 +/- 16.7 years).Results. ADC was found to depend on age at all three sites (UW, R = +0.95, P = .0003; UVa, R = +0.74, P < .0001; UN R = +0.96, P < .0001). Increases in mean ADCs with age appeared similar across sites (UW, +0.0017 cm(2)s(-1)y(-1); UVa. +0.0015 cm(2)s(-1)y(-1); pooled, +0.0015 cm(2)s(-1)y(-1); P = .71). In a regional analysis performed on UW data, the increase in ADC affected all regions of the lung, but the apical and middle regions showed a greater increase compared with the base of the lung.Conclusion. Results suggest the observed age dependence of the ADC may be caused by changes in lung microstructure that increase alveolar volume during the aging process.