Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles.
Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles.
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DOI：
10.1021/nn202410f
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发表时间：
2011-12-27
期刊：
影响因子：
17.1
通讯作者：
Shin, Dong M.
中科院分区：
文献类型：
--
作者：
Peng, Xiang-Hong;Wang, Yiqing;Huang, Donghai;Wang, Yuxiang;Shin, Hyung Juc;Chen, Zhengjia;Spewak, Michael B.;Mao, Hui;Wang, Xu;Wang, Ying;Chen, Zhuo (Georgia);Nie, Shuming;Shin, Dong M.
The clinical application of cis-diamminedichloroplatinum(II) (DDP, cisplatin) for cancer therapy is limited by its non-specific biodistribution and severe side effects. Here, we have developed EGFR-targeted heparin-DDP (EHDDP) nanoparticles for tumor targeted delivery of DDP. This nanoparticle delivery system possesses the following unique properties: i) the succinic anhydride-modified heparin is biocompatible and biodegradable with no anticoagulant activity; ii) the single chain variable fragment anti-EGFR antibody (ScFvEGFR) was conjugated to the nanoparticles as an EGFR-targeting ligand. Our results showed that EHDDP nanoparticles can significantly increase the intracellular concentrations of DDP and Pt-DNA adducts in EGFR-expressing non-small cell lung cancer H292 cells via an EGFR-mediated pathway. Compared to the free DDP, significantly prolonged blood circulation time and improved pharmacokinetics and biodistribution of Pt were observed after systemic delivery of the EHDDP nanoparticles. The new EHDDP nanoparticle delivery system significantly enhanced antitumor activity of DDP without weight loss or damage to the kidney and spleen in nude mice bearing H292 cell tumors.
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影响因子：
5.8
作者：
Clingen, P. H.;Wu, J. Y. -H.;Hartley, J. A.
通讯作者：
Hartley, J. A.
DOI：
10.1073/pnas.94.5.1739
发表时间：
1997-03-04
影响因子：
11.1
作者：
Liu, SC;Zhou, FY;Carson, DD
通讯作者：
Carson, DD
DOI：
10.1016/j.ejpb.2006.12.017
发表时间：
2007-08-01
影响因子：
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作者：
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通讯作者：
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影响因子：
7.5
作者：
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通讯作者：
Yarden, Yosef
影响因子：
5.7
作者：
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通讯作者：
Li, Chun