Lower Serum Albumin Level Is Associated With an Increased Risk for Loss of Residual Kidney Function in Patients Receiving Peritoneal Dialysis
Lower Serum Albumin Level Is Associated With an Increased Risk for Loss of Residual Kidney Function in Patients Receiving Peritoneal Dialysis
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DOI：
10.1111/1744-9987.12861
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发表时间：
2019-07-17
影响因子：
1.9
通讯作者：
Kitazono, Takanari
中科院分区：
文献类型：
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作者：
Yamada, Shunsuke;Kawai, Yasuhiro;Kitazono, Takanari
保留残余肾功能（RKF）在腹膜透析患者的管理中非常重要。然而，很少有研究探讨血清白蛋白水平和RKF损失的风险之间的关联。我们前瞻性招募了104名2006年至2016年在我院开始腹膜透析治疗的患者。主要结局是RKF完全丧失，定义为尿量< 100 mL/天。基线时的血清白蛋白水平是主要暴露。在24个月的中位观察期内，33例患者发生了RKF丢失。一个考克斯比例风险模型显示，低白蛋白血症与RKF风险增加相关，即使调整了潜在的混杂因素。多变量校正线性回归分析还显示，低白蛋白血症与24小时尿量和肾Kt/V尿素下降率更高相关。我们的研究结果表明，低白蛋白血症与腹膜透析患者RKF丢失的风险增加有关。
Preserving residual kidney function (RKF) is important in the management of patients on peritoneal dialysis. However, few studies have examined the association between serum albumin level and the risk of RKF loss. We prospectively recruited 104 patients who began peritoneal dialysis treatment at our hospital between 2006 and 2016. The primary outcome was complete RKF loss, defined as urine volume < 100 mL/day. Serum albumin level at baseline was the main exposure. During a median observation period of 24 months, 33 patients developed RKF loss. A Cox proportional hazards model showed that hypoalbuminemia was associated with an increased risk of RKF, even after adjustments for potential confounding factors. Multivariable-adjusted linear regression analysis also showed that hypoalbuminemia was associated with greater rates of decline in 24-h urine volume and in renal Kt/V urea. Our findings suggest that hypoalbuminemia is associated with an increased risk of RKF loss in patients with peritoneal dialysis.