Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.
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发表时间：
1993-08
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通讯作者：
W. Ershler;Wen-hao Sun;N. Binkley;S. Gravenstein;M. J. Volk;G. Kamoske;R. Klopp;E. Roecker;R. Daynes;R. Weindruch
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作者：
W. Ershler;Wen-hao Sun;N. Binkley;S. Gravenstein;M. J. Volk;G. Kamoske;R. Klopp;E. Roecker;R. Daynes;R. Weindruch
白细胞介素-6（IL-6）是一种多功能细胞因子，被证明是急性期炎症反应的主要贡献者。IL-6的表达通常较低，在没有炎症的情况下，血清水平通常检测不到。然而，随着年龄的增长，血清水平变得可检测，并提出这反映了该分子基因表达正常调节的年龄相关损失。也有推测认为IL-6可能有助于几种常见于晚年的疾病的发病机制，包括淋巴瘤、骨质疏松症和阿尔茨海默病。在这份报告中，我们表明，血浆中的IL-6水平上升，随着年龄的增长，精心挑选的健康老年人和老年恒河猴中的白细胞介素。我们在C57 BL/6小鼠中的发现表明，这种变化反映了初级衰老过程，其中与年龄相关的体外IL-6合成增加在很大程度上被延长寿命的饮食限制所阻止。
Interleukin-6 (IL-6) is a multifunctional cytokine that is proving to be a major contributor to the acute phase inflammatory response. IL-6 expression is normally low and serum levels are usually nondetectable in the absence of inflammation. With advancing age, however, serum levels become detectable and it is proposed that this reflects an age-associated loss in the normal regulation of gene expression for this molecule. There is also speculation that IL-6 may contribute to the pathogenesis of several diseases that are common in late-life including lymphoma, osteoporosis, and Alzheimer's disease. In this report we demonstrate that plasma levels of IL-6 rise with advancing age in well-selected healthy elderly people and comparably in old rhesus monkeys. That this change reflects a primary aging process is suggested by our findings in C57BL/6 mice in which the age-associated increase in the in vitro synthesis of IL-6 is largely prevented by life span-extending dietary restriction.