Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients.
Diet quality indices and dietary patterns are associated with plasma metabolites in colorectal cancer patients.
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饮食质量指数和饮食模式与结直肠癌患者血浆代谢物相关。
DOI：
10.1007/s00394-021-02488-1
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发表时间：
2021-09
影响因子：
5
通讯作者：
van Duijnhoven FJB
中科院分区：
文献类型：
--
作者：
Geijsen AJMR;Kok DE;van Zutphen M;Keski-Rahkonen P;Achaintre D;Gicquiau A;Gsur A;Kruyt FM;Ulrich CM;Weijenberg MP;de Wilt JHW;Wesselink E;Scalbert A;Kampman E;van Duijnhoven FJB
新出现的证据表明，饮食与结直肠癌患者的生存有关，尽管潜在的机制尚不完全清楚。本研究的目的是评估饮食暴露是否与结直肠癌患者的代谢物浓度有关。对195例I-IV期结直肠癌患者诊断时收集的血浆样本中134种代谢物的浓度进行了定量分析。使用食物频率问卷来计算世界癌症研究基金会（WCRF）饮食建议和荷兰健康饮食（DHD15）指数的遵守情况，并使用主成分分析构建饮食模式。多变量线性回归模型用于确定饮食暴露与代谢物浓度之间的关系。所有模型均根据年龄、性别、体重指数、吸烟状况、分析批次、癌症分期和使用错误发现率的多重检验进行调整。参与者的平均（SD）年龄为66(9)岁，大多数是男性（60%），大多数被诊断为II期和III期癌症。对于饮食模式分析，确定了西方，食肉和谨慎模式。更好地遵守WCRF饮食建议与较低浓度的十种磷脂酰胆碱有关。食肉动物模式的高摄入量与两种磷脂酰胆碱浓度较高有关。dhd15指数、Western模式或Prudent模式与代谢物浓度无关。在目前的研究中，WCRF饮食评分和食肉动物模式与磷脂酰胆碱有关。未来的研究应阐明磷脂酰胆碱代谢在结直肠癌连续体中的潜在相关性。ClinicalTrials.gov标识符：NCT03191110。在线版本包含补充材料，可在10.1007/s00394-021-02488-1获得。
Emerging evidence suggests that diet is linked to survival in colorectal cancer patients, although underlying mechanisms are not fully understood. The aim of this study was to evaluate whether dietary exposures are associated with metabolite concentrations in colorectal cancer patients. Concentrations of 134 metabolites of the Biocrates AbsoluteIDQ p180 kit were quantified in plasma samples collected at diagnosis from 195 stage I-IV colorectal cancer patients. Food frequency questionnaires were used to calculate adherence to the World Cancer Research Fund (WCRF) dietary recommendations and the Dutch Healthy Diet (DHD15) index as well as to construct dietary patterns using Principal Component Analysis. Multivariable linear regression models were used to determine associations between dietary exposures and metabolite concentrations. All models were adjusted for age, sex, body mass index, smoking status, analytical batch, cancer stage, and multiple testing using false discovery rate. Participants had a mean (SD) age of 66 (9) years, were mostly men (60%), and mostly diagnosed with stage II and III cancer. For the dietary pattern analyses, Western, Carnivore, and Prudent patterns were identified. Better adherence to the WCRF dietary recommendations was associated with lower concentrations of ten phosphatidylcholines. Higher intake of the Carnivore pattern was associated with higher concentrations of two phosphatidylcholines. The DHD15-index, Western pattern, or Prudent pattern were not associated with metabolite concentrations. In the current study, the WCRF dietary score and the Carnivore pattern are associated with phosphatidylcholines. Future research should elucidate the potential relevance of phosphatidylcholine metabolism in the colorectal cancer continuum. ClinicalTrials.gov Identifier: NCT03191110. The online version contains supplementary material available at 10.1007/s00394-021-02488-1.
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影响因子：
13.8
作者：
Ahmad, Shafqat;Moorthy, M. Vinayaga;Mora, Samia
通讯作者：
Mora, Samia
影响因子：
6.4
作者：
Geijsen, Anne J. M. R.;van Roekel, Eline H.;Kok, Dieuwertje E.
通讯作者：
Kok, Dieuwertje E.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.6
作者：
Menni, Cristina;Zhai, Guangju;MacGregor, Alexander;Prehn, Cornelia;Roemisch-Margl, Werner;Suhre, Karsten;Adamski, Jerzy;Cassidy, Aedin;Illig, Thomas;Spector, Tim D.;Valdes, Ana M.
通讯作者：
Valdes, Ana M.
影响因子：
7.1
作者：
O'Sullivan, Aifric;Gibney, Michael J.;Brennan, Lorraine
通讯作者：
Brennan, Lorraine