ROLE OF VASA VASORUM IN NOURISHMENT OF THE AORTIC-WALL
ROLE OF VASA VASORUM IN NOURISHMENT OF THE AORTIC-WALL
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DOI：
10.1152/ajpheart.1981.240.5.h781
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
ARMSTRONG, ML
中科院分区：
文献类型：
--
作者：
HEISTAD, DD;MARCUS, ML;ARMSTRONG, ML
血管存在于犬和人胸主动脉中膜的中层和外层。为了检查血管在主动脉营养中的作用，在麻醉的狗中结扎4对相邻的肋间动脉。这些动脉是降主动脉的血管来源，而不是主动脉弓。急性肋间结扎并没有降低主动脉弓的传导性，但降低了降主动脉中三分之一的传导性，从7 ± 1。1至3 .+-。0.7（SE）ml·cm·min-1·cm·100 g-1·cm·mmHg-1（P < 0.05）。肋间结扎后，静脉内输注腺苷（5 μ mol·cm·kg-1·cm·min-1），主动脉弓的传导性增加了3- 4倍，但降主动脉的传导性没有增加。肋间结扎后6 ~ 10天，降主动脉中1/3处的传导性仍较低。降主动脉外层血管舒张功能部分恢复，可能是通过侧支血管或新血管的形成。形态学变化范围从宽的坏死带到斑片状的细胞丢失区域，主要在降主动脉的中层。显然，血管在主动脉中膜的营养中起着关键作用。
Vasa vasorum are present in the middle and outer layers of media in the thoracic aorta of dogs and humans. To examine the role of vasa vasorum in nourishment of the aorta, 4 contiguous pairs of intercostal arteries were ligated in anesthetized dogs. These arteries are the source of vasa to the descending aorta but not the aortic arch. Blood flow through vasa vasorum was measured with microspheres. Acute intercostal ligation did not reduce conductance in the aortic arch but reduced conductance in the middle third of the descending aorta from 7 .+-. 1 to 3 .+-. 0.7 (SE) ml.cntdot.min-1.cntdot.100 g-1.cntdot.mmHg-1 (P < 0.05). After intercostal ligation, infusion of adenosine (5 .mu.mol.cntdot.kg-1.cntdot.min-1 i.v.) increased conductance in the aortic arch 3- to 4-fold but did not increase conductance in the descending aorta. Six to ten days after intercostal ligation, conductance in the middle third of the descending aorta remained low. Vasodilator capacity was partially restored in outer layers of the descending aorta, probably by collateral vessels or formation of new vessels. Morphological changes ranged from broad bands of necrosis to patchy areas of cell loss, primarily in middle layers of descending aorta. Vasa vasorum evidently are critical in the nourishment of aortic media.