Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice.
Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice.
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DOI：
10.1111/j.1601-183x.2012.00867.x
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Sah R
中科院分区：
文献类型：
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作者：
E Vollmer L;Ghosal S;A Rush J;R Sallee F;P Herman J;Weinert M;Sah R
糖皮质激素诱导受体（glucocorticoid induced receptor，GIR）是一种在前脑边缘区大量表达的应激反应基因。GIR已被归类为NPY样受体，然而，生理属性尚未研究。在目前的研究中，缺乏GIR（−/−）的小鼠在与压力，焦虑，活动，记忆，恐惧和奖励相关的各种范式中进行筛选。GIR −/−小鼠对束缚应激的致焦虑作用表现出行为不敏感性。然而，下丘脑-垂体-肾上腺（HPA）轴对应激的反应不受GIR缺乏的影响。在GIR −/−小鼠中观察到对蔗糖的偏好增加，这表明受体对奖励相关行为的调节。在GIR-/-小鼠中还观察到空间学习的延迟获得。基因型对焦虑样行为、活动和恐惧条件化消退的调节没有影响。我们的数据扩展了先前关于糖皮质激素调节GIR的研究，并为GIR在奖励，学习和压力行为结果中的作用提供了新的证据。
The glucocorticoid induced receptor (GIR) is a stress-responsive gene that is abundantly expressed in forebrain limbic regions. GIR has been classified as a NPY-like receptor, however, physiological attributes have not been investigated. In the current study mice lacking GIR (−/−) were screened in various paradigms related to stress, anxiety, activity, memory, fear and reward. GIR −/− mice elicited behavioral insensitivity to the anxiogenic effects of restraint stress. However, hypothalamic pituitary adrenal (HPA) axis response to stress was not impacted by GIR deficiency. Increased preference for sucrose was observed in GIR −/− mice suggestive of modulation of reward-associated behaviors by the receptor. A delayed acquisition of spatial learning was also observed in GIR −/− mice. There were no effects of genotype on the modulation of anxiety-like behavior, activity, and fear conditioning-extinction. Our data extend previous studies on GIR regulation by glucocorticoids and provides novel evidence for a role of GIR in reward, learning and the behavioral outcomes of stress.