Function and regulation of memory CD4 T cells
Function and regulation of memory CD4 T cells
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DOI：
10.1007/bf02786482
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发表时间：
1999-01-01
影响因子：
4.4
通讯作者：
Bottomly, K
中科院分区：
文献类型：
--
作者：
Metz, DP;Bottomly, K
外周血幼稚CD4 T细胞的发育依赖于胸腺中未成熟T细胞的阳性选择的成功。只有表达能够识别低亲和力自身mhc的T细胞受体（TCR）的胸腺细胞才能被选择存活并分化为成熟的幼稚T细胞。尽管初始T细胞的TCR必须维持自身耐受，但在抗原呈递细胞（APCs）上识别与MHC II类相关的适当外源肽时，它也会使初始CD4 T细胞增殖。成功吸收外源肽的初始CD4 T细胞会进一步分化，导致少数成熟的记忆T细胞池。尽管导致记忆T细胞发育的需求目前尚不清楚，但已经描述了功能变化，这些变化被认为与记忆T细胞对抗原的反应效率更高有关。本文将讨论通过初始和记忆CD4 T细胞的TCR信号传导相关的差异，并描述施加于记忆CD4 T细胞的独特控制机制，这些机制可能已经出现，以抵消改变的TCR信号传导。
The development of peripheral naive CD4 T cells is dependent on the success of positive selection of immature T cells in the thymus. Only thymocytes that express a T cell receptor (TCR) capable of recognizing self-MHC with low affinity are selected for survival and differentiation into mature naive T cells. Although the TCR of naive T cells has to maintain self-tolerance, it also propagates naive CD4 T cell proliferation on recognition of appropriate foreign peptide associated with MHC class II on antigen-presenting cells (APCs). Naive CD4 T cells that successfully engage foreign peptide undergo further differentiation that leads to the maturation of a select few into the memory T cell pool. Although the requirements that lead to memory T cell development are currently not known, functional changes have been described that are thought to be associated with the greater efficiency with which memory T cells respond to antigen. This article will discuss differences associated with signaling through the TCR of naive and memory CD4 T cells and describe unique control mechanisms imposed on memory CD4 T cells that are likely to have arisen to counterbalance the altered TCR signaling.