Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features.
Postoperative radiotherapy is associated with improved overall survival for alveolar ridge squamous cell carcinoma with adverse pathologic features.
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DOI：
10.1002/hed.26475
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发表时间：
2021-01
影响因子：
2.9
通讯作者：
Mowery, Yvonne M.
中科院分区：
文献类型：
--
作者：
Jacobs, Corbin D.;Williamson, Hannah;Barak, Ian;Rocke, Daniel J.;Kahmke, Russel R.;Suneja, Gita;Mowery, Yvonne M.
肺泡脊鳞状细胞癌(ARSCC)在随机试验中的代表性很差。根据国家综合癌症网络(NCCN)定义的危险因素，确定了2010至2014年间在国家癌症数据库中被诊断为患有ARSCC的成年人，他们应该考虑接受基于国家综合癌症网络(NCCN)的术后放射治疗(PORT)。在符合纳入标准的1,457名患者中，845名(58%)接受了PORT。在未调整(风险比[HR]0.83，95%可信区间[CI]0.70-0.98，P=0.02)和多变量分析(风险比0.78，95%可信区间0.64-0.94，P=0.002)中，PORT与总生存率(OS)的改善有关。PORT与有NCCN定义的危险因素1(68%比58%，P<；.001)、2(52%比31%，P<；.001)和≥3(38%比24%，P<；.001)的患者的5年OS显著改善有关。多因素分析显示，高龄、原发肿瘤大小≥3 cm、高级别、切缘阳性(S)、分期N2~3、IV/V级淋巴结转移和结外转移与预后相关。病理特征不良的切除ARSCC的端口与显著改善的OS有关。
Alveolar ridge squamous cell carcinoma (ARSCC) is poorly represented in randomized trials. Adults in the National Cancer Database diagnosed with ARSCC between 2010 and 2014 who should be considered for postoperative radiotherapy (PORT) based on National Comprehensive Cancer Network (NCCN)-defined risk factors were identified. Eight hundred forty-five (58%) of 1457 patients meeting the inclusion criteria received PORT. PORT was associated with improved overall survival (OS) on unadjusted (hazard ratio [HR] 0.83, 95% confidence interval [CI] 0.70–0.98, P = .02) and multivariable (HR 0.78, 95% CI 0.64–0.94, P = .002) analyses. PORT was associated with significantly improved 5-year OS for patients with 1 (68% vs 58%, P < .001), 2 (52% vs 31%, P < .001), and ≥3 (38% vs 24%, P < .001) NCCN-defined risk factors. Prognostic variables significantly associated with worse OS on multivariable analysis included advanced age, primary tumor size ≥3 cm, high grade, positive margin(s), stage N2-3, level IV/V nodal metastasis, and extranodal extension. PORT for resected ARSCC with adverse pathologic features is associated with significantly improved OS.
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影响因子：
1.9
作者：
Li, Chunjie;Lin, Jie;Li, Longjiang
通讯作者：
Li, Longjiang
影响因子：
3.7
作者：
Bilimoria KY;Stewart AK;Winchester DP;Ko CY
通讯作者：
Ko CY
影响因子：
3.5
作者：
Shingaki, S;Nomura, T;Nakajima, T
通讯作者：
Nakajima, T
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
通讯作者：
van Glabbeke, M
影响因子：
45.3
作者：
Allum, William H.;Stenning, Sally P.;Langley, Ruth E.
通讯作者：
Langley, Ruth E.