New Insights into the Protein Turnover Regulation in Ethylene Biosynthesis.
New Insights into the Protein Turnover Regulation in Ethylene Biosynthesis.
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对乙烯生物合成中蛋白质更新调节的新见解。
DOI：
10.14348/molcells.2015.0152
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发表时间：
2015-07
影响因子：
3.8
通讯作者：
Yoon GM
中科院分区：
文献类型：
--
作者：
Yoon GM
植物激素乙烯的生物合成受到严格的调控，以满足植物对外源和内源刺激的适当水平的乙烯的需求。1-氨基环丙烷-1-羧酸合成酶(1-氨基环丙烷-1-羧酸合成酶，1-氨基环丙烷-1-羧酸合成酶)催化乙烯生物合成的限速步骤，通过改变ACS基因的表达水平和酶的活性，对调节乙烯的产生起着核心作用。随着分子遗传学研究表明ACS的翻译后修饰的作用，新出现的证据有力地表明，除了对ACS基因的转录调控外，对ACS蛋白稳定性的调控是控制乙烯产生的另一种机制。本文综述了近年来对ACS蛋白周转调控的新见解，重点介绍了磷酸化、泛素化以及调节ACS蛋白周转的新成分的作用。还考虑了乙烯生物合成和其他信号通路之间的串扰以控制ACS蛋白周转的前景。
Biosynthesis of the phytohormone ethylene is under tight regulation to satisfy the need for appropriate levels of ethylene in plants in response to exogenous and endogenous stimuli. The enzyme 1-aminocyclopropane-1-carboxylic acid synthase (ACS), which catalyzes the rate-limiting step of ethylene biosynthesis, plays a central role to regulate ethylene production through changes in ACS gene expression levels and the activity of the enzyme. Together with molecular genetic studies suggesting the roles of post-translational modification of the ACS, newly emerging evidence strongly suggests that the regulation of ACS protein stability is an alternative mechanism that controls ethylene production, in addition to the transcriptional regulation of ACS genes. In this review, recent new insight into the regulation of ACS protein turnover is highlighted, with a special focus on the roles of phosphorylation, ubiquitination, and novel components that regulate the turnover of ACS proteins. The prospect of cross-talk between ethylene biosynthesis and other signaling pathways to control turnover of the ACS protein is also considered.