Telephone Based Cognitive Behavioral Therapy Targeting Major Depression Among Urban Dwelling, Low Income People Living with HIV/AIDS: Results of a Randomized Controlled Trial
Telephone Based Cognitive Behavioral Therapy Targeting Major Depression Among Urban Dwelling, Low Income People Living with HIV/AIDS: Results of a Randomized Controlled Trial
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DOI：
10.1007/s10461-013-0465-5
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发表时间：
2013-10-01
影响因子：
4.4
通讯作者：
Mohr, David C.
中科院分区：
文献类型：
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作者：
Himelhoch, Seth;Medoff, Deborah;Mohr, David C.
这项试验性随机对照试验评估了先前开发的基于电话的认知行为治疗（T-CBT）干预与面对面（f2 f）治疗在低收入，城市居住的HIV感染抑郁症患者中的效果。主要结局是通过抑郁量表的Hamliton评定量表测量的抑郁症状的减少。次要结果是通过随机电话药丸计数来衡量HAART的依从性。结果指标由接受过培训的研究助理收集，对治疗分配不知情。分析基于意向治疗。34名参与者符合资格标准，并被随机分配接受T-CBT（n = 16）或f2 f（n = 18）。F2 f与T-CBT相比，抑郁症治疗结果无统计学显著差异。组内评估表明，T-CBT和f2 f心理治疗组均导致抑郁症状显着减少。与f2 f治疗相比，接受T-CBT的患者更有可能坚持抗逆转录病毒药物治疗。没有参与者因不良事件而停止治疗。T-CBT可以提供给低收入，城市居住的艾滋病毒感染抑郁症的个人，导致抑郁症症状显着减少，并提高抗逆转录病毒药物的依从性。试验注册：Clinical Trial.gov标识符：NCT 01055158。
This pilot randomized controlled trial evaluated a previously developed manualized telephone based cognitive behavioral therapy (T-CBT) intervention compared to face-to-face (f2f) therapy among low-income, urban dwelling HIV infected depressed individuals. The primary outcome was the reduction of depressive symptoms as measured by the Hamliton rating scale for depression scale. The secondary outcome was adherence to HAART as measured by random telephone based pill counts. Outcome measures were collected by trained research assistants masked to treatment allocation. Analysis was based on intention-to-treat. Thirty-four participants met eligibility criteria and were randomly assigned to receive T-CBT (n = 16) or f2f (n = 18). There was no statistically significant difference in depression treatment outcomes comparing f2f to T-CBT. Within group evaluation demonstrated that both the T-CBT and the f2f psychotherapy groups resulted in significant reductions in depressive symptoms. Those who received the T-CBT were significantly more likely to maintain their adherence to antiretroviral medication compared to the f2f treatment. None of the participants discontinued treatment due to adverse events. T-CBT can be delivered to low-income, urban dwelling HIV infected depressed individuals resulting in significant reductions in depression symptoms and improved adherence to antiretroviral medication. Trial Registry: Clinical Trial.gov identifier: NCT01055158.