Are schizoaffective psychoses heterogeneous? Results of a genetic investigation, II.
Are schizoaffective psychoses heterogeneous? Results of a genetic investigation, II.
复制标题
分裂情感性精神病是否具有异质性？
DOI：
10.1016/0165-0327(79)90034-x
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发表时间：
1979
影响因子：
6.6
通讯作者：
B. Lohmeyer
中科院分区：
文献类型：
--
作者：
J. Angst;W. Felder;B. Lohmeyer
对150名情感性精神障碍先证者及其1029名一级亲属进行了检查，以寻找精神障碍的异质性。先证者的样本按几个标准划分。在不同的亚组中，将亲属的发病风险作为异质性的外部标准进行分析。女性亲属患情感性精神障碍的风险高于男性亲属。男性和女性索引患者的亲属也是如此。精神分裂症在男性和女性亲属中同样常见。分裂情感性精神病处于中间地位。进一步分析包括先证者的以下特征：首次发病年龄、发病次数、精神病理亚型（情感型、精神分裂症型、未分化型：躁狂、非躁狂）。这些标准均未证明可显著区分亚组，因此，尽管一些结果显示出预期方向的趋势，但异质性搜索结果为阴性。
150 schizoaffective probands and their 1029 first-degree relatives were examined in search of the heterogeneity of the disorder. The sample of probands was split by several criteria. Among the various subgroups the morbidity risk of relatives was analysed as an external criterion for heterogeneity. Female relatives show a higher risk for affective disorders than male relatives. This is true for relatives of male and female index patients. Schizophrenia is equally frequent in male and female relatives. Schizoaffective psychoses take an intermediate position. The further analysis included the following characteristics of the probands: age at first episode, number of episodes, psychopathological subtypes (affective, schizophrenic, undifferentiated: manic, non-manic). None of these criteria proved to distinguish subgroups significantly, therefore, the search for heterogeneity was negative, although some results show a trend to the expected direction.