Anatomo-functional correlates of auditory development in infancy
Anatomo-functional correlates of auditory development in infancy
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DOI：
10.1016/j.dcn.2019.100752
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发表时间：
2020-04-01
影响因子：
4.7
通讯作者：
Dubois, Jessica
中科院分区：
文献类型：
--
作者：
Adibpour, Parvaneh;Lebenberg, Jessica;Dubois, Jessica
婴儿的大脑发育包含了几种相互交织的机制，导致大脑网络和功能模式的强烈和异步成熟。结合脑电图（EEG）和弥散磁共振成像（MRI）的研究表明，出生后第一个学期事件相关电位（ERP）的功能成熟与相应的白色通路的结构变化有关。这里调查了类似的问题，在听觉模态。我们测量了1至6个月大的婴儿音节的ERP，并将其与扩散张量成像（DTI）测量的潜在神经基质的成熟特性相关联。我们首先观察到听觉P2的潜伏期减少，并且随着年龄的增长，听觉通道和侧裂周区域的扩散率也减少。其次，我们强调了偏侧化的一些早期功能和结构基础。对单耳音节的同侧反应比同侧反应更强更快，特别是在左半球。此外，左侧大脑半球的声辐射、弓状束、颞中回和角回的DTI表现为不对称性，其显微结构更为复杂和高级，而额下回和上级颞上回的DTI表现则相反。最后，占年龄相关的方差后，我们相关的P2反应和胼胝体纤维和下额叶区的微结构特性的个体间变异。这项研究结合专门的EEG和MRI方法在婴儿突出了听觉刺激的功能反应和相应的神经网络的成熟特性之间的复杂关系。
Infant brain development incorporates several intermingled mechanisms leading to intense and asynchronous maturation across cerebral networks and functional modalities. Combining electroencephalography (EEG) and diffusion magnetic resonance imaging (MRI), previous studies in the visual modality showed that the functional maturation of the event-related potentials (ERP) during the first postnatal semester relates to structural changes in the corresponding white matter pathways. Here investigated similar issues in the auditory modality. We measured ERPs to syllables in 1- to 6-month-old infants and related them to the maturational properties of underlying neural substrates measured with diffusion tensor imaging (DTI). We first observed a decrease in the latency of the auditory P2, and in the diffusivities in the auditory tracts and perisylvian regions with age. Secondly, we highlighted some of the early functional and structural substrates of lateralization. Contralateral responses to monoaural syllables were stronger and faster than ipsilateral responses, particularly in the left hemisphere. Besides, the acoustic radiations, arcuate fasciculus, middle temporal and angular gyri showed DTI asymmetries with a more complex and advanced microstructure in the left hemisphere, whereas the reverse was observed for the inferior frontal and superior temporal gyri. Finally, after accounting for the age-related variance, we correlated the inter-individual variability in P2 responses and in the microstructural properties of callosal fibers and inferior frontal regions. This study combining dedicated EEG and MRI approaches in infants highlights the complex relation between the functional responses to auditory stimuli and the maturational properties of the corresponding neural network.