ASSESSMENT OF THE EFFECTS OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON BLOOD FLOW THROUGH AND SALIVATION OF THE DOG SALIVARY GLAND IN COMPARISON WITH THOSE OF SECRETIN, GLUCAGON AND ACETYLCHOLINE
ASSESSMENT OF THE EFFECTS OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON BLOOD FLOW THROUGH AND SALIVATION OF THE DOG SALIVARY GLAND IN COMPARISON WITH THOSE OF SECRETIN, GLUCAGON AND ACETYLCHOLINE
复制标题
与促胰液素、胰高血糖素和乙酰胆碱相比，评估血管活性肠肽 (VIP) 对狗唾液腺血流和唾液分泌的影响
DOI：
10.1111/j.1476-5381.1979.tb07882.x
复制
发表时间：
1979
影响因子：
7.3
通讯作者：
N. Taira
中科院分区：
文献类型：
--
作者：
T. Shimizu;N. Taira
1麻醉犬，经腺动脉恒压灌注血液于原位下颌下腺血管床。所有药物均经动脉内给药。2血管活性肠肽（VIP）、胰泌素和乙酰胆碱可剂量依赖性增加动脉血流量（血管舒张），但胰高血糖素几乎无效。3 VIP和促胰液素的剂量-血流反应曲线是平行的，VIP的效力约为促胰液素的100倍（摩尔）。乙酰胆碱的剂量-血流反应曲线比VIP和促胰液素更平坦。乙酰胆碱在摩尔基础上与促胰液素的效力大致相同。4对VIP的扩血管作用无快速耐受性。5血管舒张反应VIP和电刺激的弦舌神经几乎没有修改（-）-莨菪碱的剂量，完全拮抗血管舒张反应乙酰胆碱。6 VIP、促胰液素、胰高血糖素均不能诱导唾液分泌。7讨论了VIP从副交感血管扩张神经释放并介导犬下颌下腺阿托品抵抗性血管扩张的可能性。
1 The vascular bed of the submandibular gland in situ was perfused with blood through the glandular artery at a constant pressure in anaesthetized dogs. All drugs were administered intra‐arterially. 2 Vasoactive intestinal peptide (VIP), secretin and acetylcholine produced a dose‐dependent increase in blood flow through the artery (vasodilatation) but glucagon was almost ineffective. 3 Dose‐blood flow response curves for VIP and secretin were parallel, and VIP was about 100 times as potent as secretin on a molar basis. Dose‐blood flow response curves for acetylcholine were flatter than those for VIP and secretin. Acetylcholine was approximately as potent as secretin on a molar basis. 4 No tachyphylaxis developed to the vasodilator action of VIP. 5 The vasodilator responses to VIP and to electrical stimulation of the chordolingual nerve were scarcely modified by (—)‐hyoscyamine in doses that fully antagonized the vasodilator response to acetylcholine. 6 VIP, secretin and glucagon were ineffective in eliciting salivary secretion. 7 The possibility that VIP is released from parasympathetic vasodilator nerves and mediates the atropine‐resistant vasodilatation in the dog submandibular gland is discussed.