Irrational economic decision-making after ventromedial prefrontal damage: Evidence from the ultimatum game
Irrational economic decision-making after ventromedial prefrontal damage: Evidence from the ultimatum game
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DOI：
10.1523/jneurosci.4606-06.2007
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发表时间：
2007-01-24
影响因子：
5.3
通讯作者：
Tranel, Daniel
中科院分区：
文献类型：
--
作者：
Koenigs, Michael;Tranel, Daniel
情绪调节通常对适应性决策至关重要。在这里，我们调查局灶性前额叶脑损伤后的情绪调节缺陷是否与在不公平待遇的情况下做出异常不合理的经济决策有关。在最后通牒博弈中，两个玩家有一次机会平分一笔钱。一个玩家（提议者）提供一部分钱给第二个玩家（响应者），并保留其余的钱。响应者可以接受提议（在这种情况下，两个玩家都按提议平分钱）或拒绝提议（在这种情况下，两个玩家都得不到任何东西）。相对较低的最后通牒往往被拒绝，这种“非理性”的行为被归因于对不公平待遇的情绪反应。使用损伤的方法，我们测试的假设，腹内侧前额叶皮层（VMPC），一个区域的情绪反应的调制的关键，损坏会导致夸大的非理性的经济决策。受试者作为22个不同的提议者谁提供了各种分裂的10美元的反应。报价从公平（给5美元，保留5美元）到极不公平（给1美元，保留9美元）不等。VMPC组的拒绝率高于对照组的拒绝率（7美元/3美元，8美元/2美元，9美元/1美元）。这些结果表明，情绪调节过程subserved VMPC是正常的经济决策的一个重要组成部分。
Emotion regulation is often critical for adaptive decision making. Here, we investigate whether emotion regulation defects following focal prefrontal brain damage are associated with exceptionally irrational economic decision making in situations of unfair treatment. In the Ultimatum Game, two players are given one opportunity to split a sum of money. One player (the proposer) offers a portion of the money to the second player (the responder) and keeps the rest. The responder can either accept the offer (in which case both players split the money as proposed) or reject the offer (in which case both players get nothing). Relatively low Ultimatum offers are often rejected, and this "irrational" behavior has been attributed to an emotional reaction to unfair treatment. Using the lesion method, we tested the hypothesis that damage to ventromedial prefrontal cortex (VMPC), an area critical for the modulation of emotional reactions, would result in exaggerated irrational economic decisions. Subjects acted as the responder to 22 different proposers who offered various splits of $10. Offers ranged from fair (give $5, keep $5) to extremely unfair (give $1, keep $9). The rejection rate of the VMPC group was higher than the rejection rates of the comparison groups for each of the most unfair offers ($7/$3, $8/$2, $9/$1). These results suggest that emotion regulation processes subserved by VMPC are a critical component of normal economic decision making.