The Use of Opioids for Treatment of Pediatric Neuropathic Pain: A Literature Review.
The Use of Opioids for Treatment of Pediatric Neuropathic Pain: A Literature Review.
复制标题
使用阿片类药物治疗小儿神经性疼痛：文献综述。
DOI：
10.1097/ajp.0000000000000712
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Anderson,Annette
中科院分区：
文献类型：
--
作者：
Windsor,RobertB;Tham,SeeWan;Adams,TrevorL;Anderson,Annette
儿科神经性疼痛是由一系列疾病引起的，这些疾病通常很难治疗。许多潜在的神经过程改变正在通过机制研究得到阐明。很少有随机对照试验评估阿片类药物治疗成人神经性疼痛的情况，在儿科人群中也没有。由于提供指导的数据稀少，对潜在机制的理解不完整，阿片类药物的使用仍然不清楚。我们的临床经验和典型的风险与获益考虑表明，使用阿片类药物治疗小儿神经性疼痛的作用有限（如果有的话）。在这篇文献综述中，我们回顾了现有的成人和儿童数据，并提供了关于这一主题的一般指导。
Pediatric neuropathic pain is caused by a spectrum of disorders that are generally challenging to treat. Many of the underlying altered neurological processes are being elucidated through mechanistic studies. Few randomized control trials have evaluated the use of opioids for the treatment of adult neuropathic pain conditions, and there have been none in pediatric populations. With sparse data to provide guidance and an incomplete understanding of the underlying mechanisms, the use of opioids remains unclear. Our clinical experience and typical risk versus benefit considerations suggest a limited, if any, role for using opioids to treat pediatric neuropathic pain. In this literature review, we review the available adult and pediatric data and provide general guidance on this subject matter.