Travelers Can Import Colistin-Resistant Enterobacteriaceae, Including Those Possessing the Plasmid-Mediated mcr-1 Gene
Travelers Can Import Colistin-Resistant Enterobacteriaceae, Including Those Possessing the Plasmid-Mediated mcr-1 Gene
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DOI：
10.1128/aac.00731-16
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发表时间：
2016-08-01
影响因子：
4.9
通讯作者：
Endimiani, Andrea
中科院分区：
文献类型：
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作者：
Bernasconi, Odette J.;Kuenzli, Esther;Endimiani, Andrea
从38名从印度返回的旅行者粪便样本进行了筛选超广谱头孢菌素和碳青霉烯类耐药肠杆菌执行标准选择性平板。26例（76.3%）患者定植有CTX-M或DHA生产者，但没有菌株为粘菌素耐药和/或mcr-1阳性。然而，使用过夜富集和CHROMagar方向板补充粘菌素，发现4人（10.5%）与粘菌素耐药大肠杆菌定殖。一种头孢菌素敏感序列类型10（ST 10）菌株在IncHI 2质粒骨架中携带4，211-bp ISApl 1-mcr-1-ISApl 1元件。
Stool samples from 38 travelers returning from India were screened for extended-spectrum cephalosporin- and carbapenem-resistant Enterobacteriaceae implementing standard selective plates. Twenty-six (76.3%) people were colonized with CTX-M or DHA producers, but none of the strains was colistin resistant and/or mcr-1 positive. Nevertheless, using overnight enrichment and CHROMagar Orientation plates supplemented with colistin, four people (10.5%) were found to be colonized with colistin-resistant Escherichia coli. One cephalosporin-susceptible sequence type 10 (ST10) strain carried a 4,211-bp ISApl1-mcr-1-ISApl1 element in an IncHI2 plasmid backbone.