Melatonin and Regulation of Immune Function: Impact on Numerous Diseases.
Melatonin and Regulation of Immune Function: Impact on Numerous Diseases.
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DOI：
10.2174/1874609813666200711153223
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发表时间：
2020-01-01
影响因子：
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通讯作者：
Campbell, Arezoo
中科院分区：
文献类型：
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作者：
Bondy, Stephen C;Campbell, Arezoo
褪黑激素是众所周知的促进睡眠的神经内分泌激素。然而，褪黑激素的许多其他属性不太明显，也没有得到广泛的认可。本文就褪黑素与免疫功能的关系作一综述。褪黑激素在部分或全部恢复最佳功能的相关性，在一系列与免疫功能障碍有关的疾病中，在本报告中讨论。这包括自身免疫性疾病和许多其他涉及异常免疫反应的疾病的潜在缓解，包括随着衰老而发生的身体防御有效性的整体下降。影响广泛器官系统的疾病状态已被报道为受益于褪黑激素管理，并在这里讨论。一个单独的部分解决褪黑激素在减轻与年龄有关的神经系统疾病的潜在作用，鉴于这一领域的重要性日益增加。褪黑激素可能通过其对免疫功能的作用而提供保护的特性的可能机制基础也被描述。
Melatonin is well known as a neuroendocrine hormone that promotes sleep. However, the many other attributes of melatonin are less apparent and not as widely appreciated. The purpose of this review is to summarize the qualities of melatonin relating to immune function. The relevance of melatonin in partially or wholly restoring optimal function, in a series of disorders related to immune dysfunction, is addressed in this report. This includes the potential relief of both autoimmune diseases and many other ailments involving abnormal immune responses, including the overall diminished effectiveness of body defenses occurring with aging. Disease states affecting a wide range of organ systems have been reported as benefitting from melatonin administration and are discussed here. A separate section addresses the potential role of melatonin in the mitigation of age-related neurological diseases, in view of the increasing importance of this area. The likely mechanistic basis of the properties by which melatonin may confer protection by its acting on immune function is also described.