The Neutrophil-to-Lymphocyte ratio as a marker of recovery status in patients with severe dental infection
The Neutrophil-to-Lymphocyte ratio as a marker of recovery status in patients with severe dental infection
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DOI：
10.4317/medoral.21915
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发表时间：
2017-07-01
影响因子：
2.2
通讯作者：
Alkan, Alper
中科院分区：
文献类型：
--
作者：
Dogruel, Fatma;Gonen, Zeynep-Burcin;Alkan, Alper
背景资料：本研究的目的是评估预处理中性粒细胞/淋巴细胞（N/L）比值和平均血小板体积（MPV）的价值和这些标志物与严重牙源性感染患者的进展之间的相关性。材料和方法：100例严重牙源性感染患者的队列被分为2组，根据其住院时间的长短。所有患者均测量N/L比值和MPV。分析所有患者术前发热、术前抗生素用量、术后抗生素用量、抗生素总用量及住院时间与N/L比值和MPV的相关性。结果：N/L比值与术后住院时间、术后抗生素用量及总抗生素用量呈正相关，且具有统计学意义。ROC分析结果显示，N/L比值的最佳截断值为5.19.结论：N/L比值可作为牙源性感染患者的预后指标。当检测到N/L比值大于5.19时，这些患者可能需要更高剂量的抗生素，并住院治疗牙源性感染超过1天。
Background: The aim of the study was to assess the value of pretreatment neutrophil/lymphocyte (N/L) ratio and mean platelet volume (MPV) and the correlation between these markers with progression in patients with severe odontogenic infection.Material and Methods: A cohort of 100 patients with severe odontogenic infection were divided into 2 groups according to their length of hospital stay. The N/L ratio and MPV was measured in all patients. The correlation in all patients between preoperative fever, preoperative antibiotic doses, postoperative antibiotic doses, total antibiotic doses and hospital stay with N/L ratio and MPV were analyzed. The Youden index was used to identify the optimal cut-off value.Results: There were positive and statistically significant correlations between N/L ratio and prolonged hospital stay and postoperative antibiotic doses and total antibiotic doses. The optimum cut -off level of N/L ratio was 5.19 according to ROC analysis. However, there was no correlation between MPV and any of these parameters.Conclusions: N/L ratio may be used as a prognostic marker for patients with odontogenic infections. These patients may need a higher dose of antibiotics and stay more than 1 day in hospital for the treatment of odontogenic infection when the N/L ratio is detected to be more than 5.19.