BREAST-CANCER INCIDENCE IN WOMEN WITH A HISTORY OF PROGESTERONE DEFICIENCY
BREAST-CANCER INCIDENCE IN WOMEN WITH A HISTORY OF PROGESTERONE DEFICIENCY
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DOI：
10.1093/oxfordjournals.aje.a113184
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发表时间：
1981-01-01
影响因子：
5
通讯作者：
JONES, GS
中科院分区：
文献类型：
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作者：
COWAN, LD;GORDIS, L;JONES, GS
为了调查非自愿推迟第一胎出生与乳腺癌风险之间的关系，对 1945 年至 1965 年间接受不孕症评估和治疗的 1083 名白人妇女进行了前瞻性随访，直至 1978 年 4 月，以确定她们的乳腺癌发病率。这些女性根据不孕原因分为两类：内源性黄体酮缺乏症（PD）和非激素原因（NH）。 PD组女性患绝经前乳腺癌的风险是NH组女性的5.4倍。这种超额风险不能用两组之间初潮或绝经年龄、口服避孕药使用史、良性乳腺疾病史或第一胎年龄的差异来解释。与 NH 组相比，PD 组女性死于所有恶性肿瘤的人数也增加了 10 倍。绝经后乳腺癌的发病率在两组之间没有显着差异。
To investigate the nature of the association of involuntarily delayed 1st birth and risk of breast cancer, 1083 white women evaluated and treated for infertility from 1945-1965 were followed prospectively through April 1978 to ascertain their breast cancer incidence. These women were categorized as to the cause of infertility into 2 groups, those with endogenous progesterone deficiency (PD) and those with nonhormonal causes (NH). Women in the PD group had 5.4 times the risk of premenopausal breast cancer compared to women in the NH group. This excess risk could not be explained by differences between the 2 groups in ages at menarche or menopause, history of oral contraceptive use, history of benign breast disease or age at first birth. Women in the PD group also experienced a 10-fold increase in deaths from all malignant neoplasms compared to the NH group. The incidence of postmenopausal breast cancer did not differ significantly between the 2 groups.