Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data
Mouse Phenome Database: a data repository and analysis suite for curated primary mouse phenotype data
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DOI：
10.1093/nar/gkz1032
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发表时间：
2020-01-08
影响因子：
14.9
通讯作者：
Chesler, Elissa J.
中科院分区：
文献类型：
--
作者：
Bogue, Molly A.;Philip, Vivek M.;Chesler, Elissa J.
小鼠表型数据库（MPD; https://phenome.jax.org）是一个广泛访问和高度功能性的数据储存库，其中包含可通过API访问的实验室小鼠的主要表型数据，并提供分析和可视化这些数据的工具。数据来自世界各地的研究人员，代表了幼稚小鼠和暴露于药物、环境因子或其他治疗的小鼠的广泛表型终点和疾病相关性状。MPD拥有严格管理的每只动物数据和详细的方案。公共本体和受控词汇表用于注释。除了表型工具，遗传分析工具使用户能够整合和解释整个数据库的基因组-表型关系。品系类型和群体包括近交系、重组近交系、F1杂种、转基因、靶向突变体、染色体置换、协作杂交、多样性远交和其他作图群体。我们的新分析工具允许用户以综合的方式应用选定的数据，以解决性状关联、再现性、多基因综合征模型选择和多性状建模中的问题。在我们完善这些工具和方法的同时，我们将继续为用户提供一种方法，以识别具有高度翻译相关性的一致的、高质量的研究。
The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely accessed and highly functional data repository housing primary phenotype data for the laboratory mouse accessible via APIs and providing tools to analyze and visualize those data. Data come from investigators around the world and represent a broad scope of phenotyping endpoints and disease-related traits in naive mice and those exposed to drugs, environmental agents or other treatments. MPD houses rigorously curated per-animal data with detailed protocols. Public ontologies and controlled vocabularies are used for annotation. In addition to phenotype tools, genetic analysis tools enable users to integrate and interpret genome-phenome relations across the database. Strain types and populations include inbred, recombinant inbred, F1 hybrid, transgenic, targeted mutants, chromosome substitution, Collaborative Cross, Diversity Outbred and other mapping populations. Our new analysis tools allow users to apply selected data in an integrated fashion to address problems in trait associations, reproducibility, polygenic syndrome model selection and multi-trait modeling. As we refine these tools and approaches, we will continue to provide users a means to identify consistent, quality studies that have high translational relevance.