Modeling the mechanisms of acute hepatitis B virus infection
Modeling the mechanisms of acute hepatitis B virus infection
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DOI：
10.1016/j.jtbi.2007.02.017
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发表时间：
2007-07-07
影响因子：
2
通讯作者：
Perelson, Alan S.
中科院分区：
文献类型：
--
作者：
Ciupe, Stanca M.;Ribeiro, Ruy M.;Perelson, Alan S.
数学模型已被用于了解病毒感染中控制传染病进展的因素。在这里，我们专注于B型肝炎病毒（HBV）感染的急性阶段的动力学和分析负责病毒清除的免疫机制。我们首先介绍用于解释在慢性感染患者中进行的乙型肝炎治疗研究的基本模型。然后，我们引入了其他模型来研究急性感染，其中免疫反应可能在确定感染是否会被清除或成为慢性方面发挥重要作用。我们逐步增加复杂性，并解释建模过程的每一步。最后，我们根据实验数据验证模型，以确定它代表生物系统的程度，从而确定它的预测有多有用。特别是，我们发现细胞介导的免疫反应在病毒载量峰值后控制病毒方面起着重要作用。爱思唯尔有限公司出版
Mathematical models have been used to understand the factors that govern infectious disease progression in viral infections. Here we focus on hepatitis B virus (HBV) dynamics during the acute stages of the infection and analyze the immune mechanisms responsible for viral clearance. We start by presenting the basic model used to interpret HBV therapy studies conducted in chronically infected patients. We then introduce additional models to study acute infection where immune responses presumably play an important role in determining whether the infection will be cleared or become chronic. We add complexity incrementally and explain each step of the modeling process. Finally, we validate the model against experimental data to determine how well it represents the biological system and, consequently, how useful are its predictions. In particular, we find that a cell-mediated immune response plays an important role in controlling the virus after the peak in viral load. Published by Elsevier Ltd.