Tirucallane-type triterpenoids from Dysoxylum lenticellatum.
Tirucallane-type triterpenoids from Dysoxylum lenticellatum.
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DOI：
10.1021/np2006296
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发表时间：
2011-09
影响因子：
5.1
通讯作者：
Hong-li Huang;Chun-Ming Wang;Zhen-hua Wang;Ming-Jun Yao;Guang-Tian Han;Ji-Cheng Yuan;K. Gao;Cheng‐Shan Yuan
中科院分区：
文献类型：
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作者：
Hong-li Huang;Chun-Ming Wang;Zhen-hua Wang;Ming-Jun Yao;Guang-Tian Han;Ji-Cheng Yuan;K. Gao;Cheng‐Shan Yuan
本文报道了十个新的替鲁卡拉烷型三萜化合物，包括一个重排骨架的dysolenticin A（1），dysolenticin B（2），一个罕见的三降三萜化合物dysolenticin C（3），三个具有半缩酮结构的替鲁卡拉烷三萜衍生物dysolenticins D-F（4-6），dysolenticins G-I（7，9，10）和新生物碱dysolenticin J（12），以及7个已知类似物从Dysoxylum spellatum的枝叶中分离得到。它们的结构通过广泛的光谱方法进行了鉴定，化合物1、3、4、6和10的结构通过单晶X射线衍射实验进行了证实。Dysolenticin J（12）对大鼠完整主动脉环有明显的舒张作用，10 μg/mL时舒张度为87.4%。
Ten new tirucallane-type triterpenoids, represented by a rearranged skeleton dysolenticin A (1), dysolenticin B (2), a rare trinortriterpenoid dysolenticin C (3), three tirucallane triterpenoid derivatives with a hemiketal moiety dysolenticins D-F (4-6), dysolenticins G-I (7, 9, 10), and the new alkaloid dysolenticin J (12), together with seven known analogues were isolated from the twigs and leaves of Dysoxylum lenticellatum. Their structures were elucidated by extensive spectroscopic methods, and those of compounds 1, 3, 4, 6, and 10 were confirmed by single-crystal X-ray diffraction experiments. Dysolenticin J (12) showed significant vasodilative effects on intact rat aortic rings with a diastolic degree of 87.4% at 10 μg/mL.