Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution
Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution
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亚洲虎蚊（白纹伊蚊）的基因组序列揭示了对其生物学、遗传学和进化的见解
DOI：
10.1073/pnas.1516410112
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发表时间：
2015-11-03
影响因子：
11.1
通讯作者：
James, Anthony A.
中科院分区：
文献类型：
--
作者：
Chen, Xiao-Guang;Jiang, Xuanting;James, Anthony A.
亚洲虎蚊（白纹伊蚊）是一种非常成功的入侵物种，可传播多种人类病毒性疾病，包括登革热和基孔肯雅热。该物种拥有庞大的基因组，并且具有显着的基于种群的大小差异。佛山品系的完整基因组序列已确定，佛山品系是一个已建立的实验室群体，源自中国东南部的野生蚊子，该地区位于该物种起源的历史范围内。该基因组包含 1,967 Mb，是迄今为止测序的最大的蚊子基因组，其大小主要来自于大量的重复 DNA 类别。此外，涉及杀虫剂抗性机制、滞育、性别决定、免疫和嗅觉的基因家族成员数量的增加也导致了体型的增大。整合的黄病毒样基因组的部分支持这些病毒与其载体关联的共同进化历史。庞大的基因组库可能有助于伊蚊的适应性和成功。白纹伊蚊为入侵物种。
The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes from southeastern China, a region within the historical range of the origin of the species. The genome comprises 1,967 Mb, the largest mosquito genome sequenced to date, and its size results principally from an abundance of repetitive DNA classes. In addition, expansions of the numbers of members in gene families involved in insecticide-resistance mechanisms, diapause, sex determination, immunity, and olfaction also contribute to the larger size. Portions of integrated flavivirus-like genomes support a shared evolutionary history of association of these viruses with their vector. The large genome repertory may contribute to the adaptability and success of Ae. albopictus as an invasive species.