ROLE OF AMYGDALOID COMPLEXES IN STRESS-INDUCED RELEASE OF ACTH IN RAT
ROLE OF AMYGDALOID COMPLEXES IN STRESS-INDUCED RELEASE OF ACTH IN RAT
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DOI：
10.1159/000122310
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发表时间：
1974-01-01
影响因子：
4.1
通讯作者：
ALLEN, CF
中科院分区：
文献类型：
--
作者：
ALLEN, JP;ALLEN, CF
用成年雄性大鼠研究杏仁核复合体在应激诱导的ACTH释放中的作用。单侧和/或双侧射频损伤位于杏仁核或其传出通路。测定腿部骨折、止血带或乙醚应激后的血浆皮质酮浓度。单侧杏仁核损伤不能阻止对侧使用止血带或断腿的效果。双侧杏仁核病变可阻断腿部断裂的影响，但不能阻断乙醚或止血带。双侧下丘脑外侧区和杏仁核之间的双侧病变也可阻断断腿效应，但不能阻断乙醚或止血带，而终纹前部的双侧病变不能阻断断腿效应。这些数据表明，杏仁核促进而不是直接传递神经源性应激诱导的信号(断腿)，而不是来自全身应激的信号(乙醚)。此外，一个杏仁体复合体似乎足以达到这种效果。参与易化效应的从杏仁核到下丘脑的通路可能是直接向下丘脑的内侧投射。
The participation of the amygdaloid complexes in the stress-induced release of ACTH was studied in the adult male rat. Unilateral and/or bilateral radiofrequency lesions were placed in the amygdalae or their efferent pathways. Plasma corticosterone concentrations were measured after either a leg break, tourniquet, or ether stress. Unilateral amygdaloid lesions did not block the effect of a contralaterally-applied tourniquet or leg break. Bilateral paired amygdaloid lesions blocked the effect of the leg break but not of ether or tourniquet. Bilateral paired lesions between the lateral hypothalamic area and the amygdalae also blocked the effect of the leg break but not ether or tourniquet, whereas bilateral lesions in the anterior portion of the striae terminali did not block the leg-break effect. These data suggest that the amygdalae facilitate rather than directly transmit neurogenic stress-induced signals (leg break) but not signals from systemic stresses (ether). Furthermore, one amygdaloid complex appears to be sufficient for achieving this effect. The pathway from the amygdalae to the hypothalamus involved in the facilitatory effect is probably a direct medial projection to the hypothalamus.