Cytoskeletal diversification across 1 billion years: What red algae can teach us about the cytoskeleton, and vice versa
Cytoskeletal diversification across 1 billion years: What red algae can teach us about the cytoskeleton, and vice versa
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DOI：
10.1002/bies.202000278
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发表时间：
2021-04-01
期刊：
影响因子：
4
通讯作者：
Brawley，Susan H.
中科院分区：
文献类型：
--
作者：
Goodson，Holly V.;Kelley，Joshua B.;Brawley，Susan H.
细胞骨架在真核生物学中起着核心作用，使细胞能够进行内部组织、迁移和易位。研究整个生命树的细胞骨架机制可以识别共同元素，阐明基本机制，并提供对特征较少的生物体特有过程的洞察。红藻代表了一个古老的谱系，具有多样性，生态意义和生物医学相关性。最近的基因组分析表明，红藻有一个令人惊讶的缺乏细胞骨架元素，特别是分子马达。在这里，我们回顾了基因组和细胞生物学证据，并提出了可测试的模型，红藻细胞如何可能执行的过程，包括细胞运动，胞质分裂，细胞内运输和分泌，鉴于其减少的细胞骨架。除了增强对红藻和从红藻内共生体进化而来的谱系的理解外（例如，apicomplexan寄生虫），这些想法也可能提供深入了解动物细胞中的细胞骨架过程。
The cytoskeleton has a central role in eukaryotic biology, enabling cells to organize internally, polarize, and translocate. Studying cytoskeletal machinery across the tree of life can identify common elements, illuminate fundamental mechanisms, and provide insight into processes specific to less‐characterized organisms. Red algae represent an ancient lineage that is diverse, ecologically significant, and biomedically relevant. Recent genomic analysis shows that red algae have a surprising paucity of cytoskeletal elements, particularly molecular motors. Here, we review the genomic and cell biological evidence and propose testable models of how red algal cells might perform processes including cell motility, cytokinesis, intracellular transport, and secretion, given their reduced cytoskeletons. In addition to enhancing understanding of red algae and lineages that evolved from red algal endosymbioses (e.g., apicomplexan parasites), these ideas may also provide insight into cytoskeletal processes in animal cells.