Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata
Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata
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DOI：
10.1055/s-2006-957836
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发表时间：
1996-04-01
期刊：
影响因子：
2.7
通讯作者：
Bye, R
中科院分区：
文献类型：
--
作者：
MartinezVazquez, M;Apan, TOR;Bye, R
醉鱼草（Loganiaceae）叶子的干燥水提取物及其主要黄酮苷 linarin 已分别在小鼠和大鼠中进行镇痛和解热作用评估。提取物和亚麻苷均发挥显着且剂量依赖性的镇痛和解热活性，第一个是针对化学刺激（小鼠扭体试验）获得的，第二个是通过致热刺激（酵母诱导的高热试验）获得的。此外，动物在热板测试中的反应被亚麻苷和水提取物改变。这些活性与硫酸吗啡 (MS) 所显示的活性相似，并且它们被纳索龙预处理（一种特定的吗啡拮抗剂化合物）所抑制。这些发现得出这样的结论：水提取物和里那林发挥中枢镇痛特性。另一方面，linarin 被证明负责该物种的解热活性。
The dried aqueous extract of leaves of Buddleia cordata (Loganiaceae) and its main flavonoid glycoside, linarin, have been evaluated for analgesic and antipyretic effects in mice and rats, respectively. Both the extract and linarin exerted significant and dose-dependent analgesic and antipyretic activities, the first being obtained against a chemical stimulus (writhing test in mice) and the second being obtained by a pyretogenic stimulus (yeast-induced hyperthermia test). Furthermore, the response of the animals in the hot plate test was modified by linarin and an aqueous extract. These activities were similar to that showed by morphine sulfate (MS) and they were inhibited by naxolone pretreatment, a specific morphinic antagonist compound. These findings lead to the conclusion that the aqueous extract and linarin exert central analgesic properties. On the other hand, linarin was shown to be responsible for the antipyretic activity of this species.