Inhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile enterotoxin requires an enzymatically active A subunit.
Inhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile enterotoxin requires an enzymatically active A subunit.
复制标题
大肠杆菌不耐热肠毒素对 II 类主要组织相容性复合物抗原加工的抑制需要具有酶活性的 A 亚基。
DOI：
10.1128/iai.66.7.3480-3484.1998
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发表时间：
1998
影响因子：
3.1
通讯作者：
Harding,CV
中科院分区：
文献类型：
--
作者：
Matousek,MP;Nedrud,JG;CieplakJr,W;Harding,CV
Escherichia coliheat-labile enterotoxin (LT) and cholera toxin (CT) were found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex complexes. Inhibition of antigen processing correlated with A subunit ADP-ribosyltransferase activity.
