Gonadectomy and persistent pain differently affect hippocampal c-Fos expression in male and female rats
Gonadectomy and persistent pain differently affect hippocampal c-Fos expression in male and female rats
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DOI：
10.1016/s0304-3940(00)00819-3
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发表时间：
2000-03-03
影响因子：
2.5
通讯作者：
Herdegen, T
中科院分区：
文献类型：
--
作者：
Aloisi, AM;Ceccarelli, I;Herdegen, T
研究了雄性和雌性大鼠在性腺切除和持续疼痛后海马c-Fos的表达。手术后三周，动物被假注射或注射福尔马林（50 μ l, 10%），并置于熟悉的测试设备中。记录注射后足爪舔、挠、抽搐60 min，测定海马背侧和腹侧：齿状回（DG）、CA1和CA3的c-Fos。性腺切除术导致两性DG背侧、雄性所有腹侧亚区和雌性腹侧CA3区c-Fos升高。在正常男性和女性中，福尔马林增加了DG背侧和男性腹侧亚野的c-Fos。在去腺细胞的小鼠中，福尔马林降低或不改变c-Fos。性腺切除术导致男性和女性弯曲时间延长。这些数据表明性腺激素、伤害性输入和海马神经元活动之间存在重要的性别依赖相互作用。(C) 2000爱思唯尔科学爱尔兰有限公司版权所有。
Hippocampal c-Fos expression was studied in male and female rats after gonadectomy and persistent pain. Three weeks after surgery, animals were sham- or formalin-injected (50 mu l, 10%) and placed in a familiar testing apparatus. The formalin-evoked licking, flexing and jerking of the injected paw were recorded for 60 min, c-Fos was determined in the dorsal and ventral hippocampus: dentate gyrus (DG), CA1 and CA3. Gonadectomy induced higher c-Fos in the dorsal DG of both sexes, in all ventral subfields of males and in the ventral CA3 of females. In normal males a nd females, formalin increased c-Fos in the dorsal DG and in the male ventral subfields. In gonadectomized ones formalin decreased or did not change c-Fos. Gonadectomy induced longer flexing in males and females. These data indicate an important and sex-dependent interaction between gonadal hormones, nociceptive input and neuronal activity in the hippocampus. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.