The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure.
The Circadian Clock in the Ventromedial Hypothalamus Controls Cyclic Energy Expenditure.
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DOI：
10.1016/j.cmet.2016.02.003
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发表时间：
2016-03-08
期刊：
影响因子：
29
通讯作者：
Sassone-Corsi P
中科院分区：
文献类型：
--
作者：
Orozco-Solis R;Aguilar-Arnal L;Murakami M;Peruquetti R;Ramadori G;Coppari R;Sassone-Corsi P
有机体内平衡依赖于组织之间的一致相互作用，特别是大脑驱动的功能和周围代谢器官之间的相互作用。下丘脑回路计算代谢信息以优化能量资源，但生物钟在这些途径中的作用仍不清楚。我们培育出了对腹内侧下丘脑 (VMH) 的 Sf1 神经元内的核心时钟基因 Bmal1 进行靶向消融的小鼠。虽然这种突变不会影响视交叉上核 (SCN) 的中央时钟，但 VMH 时钟控制棕色脂肪组织 (BAT) 的循环生热作用，棕色脂肪组织是一种通过将化学能以热量形式耗散来控制能量平衡的组织。 VMH 驱动的控制是通过增加交感神经系统内的肾上腺素信号传导来实现的，而不影响 BAT 的内源时钟。此外，我们表明 VMH 生物钟计算光和进食输入来调节基础能量消耗。因此，我们揭示了一个以前未曾怀疑过的回路，其中独立于 SCN 的下丘脑生物钟控制着 BAT 功能、能量消耗和生热作用。
Organismal homeostasis relies on coherent interactions among tissues, specifically between brain-driven functions and peripheral metabolic organs. Hypothalamic circuits compute metabolic information to optimize energetic resources, but the role of the circadian clock in these pathways remains unclear. We have generated mice with targeted ablation of the core-clock gene Bmal1 within Sf1-neurons of the ventromedial hypothalamus (VMH). While this mutation does not affect the central clock in the suprachiasmatic nucleus (SCN), the VMH clock controls cyclic thermogenesis in brown adipose tissue (BAT), a tissue that governs energy balance by dissipating chemical energy as heat. VMH-driven control is exerted through increased adrenergic signaling within the sympathetic nervous system, without affecting the BAT’s endogenous clock. Moreover, we show that the VMH circadian clock computes light and feeding inputs to modulate basal energy expenditure. Thus, we reveal a previously unsuspected circuit where an SCN-independent, hypothalamic circadian clock controls BAT function, energy expenditure and thermogenesis.
影响因子：
6.5
作者：
Meng, Xia;Chen, Jian;Zeng, Wenwen
通讯作者：
Zeng, Wenwen