First asymmetric total syntheses of (-)-subincanadines a and B, skeletally rearranged pentacyclic monoterpenoid indole alkaloids in aspidospermasubincanum.
First asymmetric total syntheses of (-)-subincanadines a and B, skeletally rearranged pentacyclic monoterpenoid indole alkaloids in aspidospermasubincanum.
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DOI：
10.1021/ol061908i.s001
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发表时间：
2006
期刊：
影响因子：
5.2
通讯作者：
Kenta Suzuki;H. Takayama
中科院分区：
文献类型：
--
作者：
Kenta Suzuki;H. Takayama
我们首次实现了新的Aspidosperma吲哚生物碱（-）-subincanderine A和B的不对称全合成，其中包括分子内非对映选择性的Pictet-Spengler环合反应和分子内Nozaki-Hiyama-Kishi反应。
We achieved the first asymmetric total syntheses of novel Aspidosperma indole alkaloids, (-)-subincanadines A and B, which involve an intramolecular diastereoselective Pictet-Spengler cyclization and an intramolecular Nozaki-Hiyama-Kishi reaction as key steps in the total syntheses.