COCAINE-INDUCED COCAINE CRAVING
COCAINE-INDUCED COCAINE CRAVING
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DOI：
10.1007/bf00443414
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发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
SHERER, MA
中科院分区：
文献类型：
--
作者：
JAFFE, JH;CASCELLA, NG;SHERER, MA
在 9 名有经验的可卡因使用者中，我们检查了在静脉注射 (IV) 可卡因 40 毫克剂量（有或没有口服 2.5 毫克溴隐亭）预处理后使用可卡因或其他药物的冲动。使用可卡因的冲动是通过一份问卷来评估的，该问卷旨在评估对可卡因或其他药物的“想要”和“渴望”。服用可卡因后十五分钟（但服用安慰剂后则不然），受试者对药物“想要”和药物“渴望”的评价均显着增加。我们的研究结果提供了可卡因引起人类吸毒冲动增加的实验室证明。研究结果强调了与药物管理相关的内部刺激的作用，表明有可能区分重复使用药物的动机波动水平的相关但可能不同的组成部分。
In nine experienced users of cocaine, we examined the urge to use cocaine or other drugs following a 40 mg dose of intravenous (IV) cocaine with and without oral pretreatment with 2.5 mg bromocriptine. The urge to use cocaine was assessed with a questionnaire constructed to assess both "wanting" and "craving" for cocaine or other drugs. Fifteeen minutes after the administration of cocaine (but not after placebo), subjects'' rating for both drug "wanting" and drug "craving" were significantly increased. Our results provide a laboratory demonstration of cocaine-induced increases in the urge to use drugs in humans. The findings, stressing the role of internal stimuli associated with drug administration, suggest the possibility of distinguishing among related, but perhaps distinct, components of the fluctuating levels of motivation to reuse drugs.