TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.
TLR2, TLR4 and TLR9 genotypes and haplotypes in the susceptibility to and clinical course of Chlamydia trachomatis infections in Dutch women.
复制标题
TLR2、TLR4 和 TLR9 基因型和单倍型与荷兰女性沙眼衣原体感染的易感性和临床病程相关。
DOI：
10.1093/femspd/ftv107
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发表时间：
2016
影响因子：
3.3
通讯作者：
Ouburg,Sander
中科院分区：
文献类型：
--
作者：
Verweij,StephanP;Karimi,Ouafae;Pleijster,Jolein;Lyons,JosephM;deVries,HenryJC;Land,JolandeA;Morré,ServaasA;Ouburg,Sander
Chlamydia trachomatisinfections demonstrate remarkable differences in clinical course that are approximately 40% based on host genetic variation. Here, we study the single nucleotide polymorphisms (SNPs) and their haplotypes inTLR2, TLR4andTLR9(TLR2+2477G>A;TLR2–16934T>A;TLR4+896A>G;TLR9–1237T>C andTLR9+2848G>A) in relation to the susceptibility to, and severity ofC. trachomatisinfections. We analysed the five SNPs in a cohort of 770 Dutch Caucasian women either attending a sexually transmitted diseases outpatient clinic (n = 731) or having complaints of subfertility (n = 39). Haplotype analyses showed a trend forTLR2haplotype I (–16934T/+2477G) to protect against the development of symptoms and tubal pathology (Ptrend= 0.03) afterChlamydiainfection. In the susceptibility cohort,TLR9haplotype III (–1237C/+2848A) showed a significant decreasing trend in the development of symptoms afterC. trachomatisinfection (P= 0.02, OR: 0.55, 95%CI: 0.33–0.91). Logistic regression of theTLR2haplotypes,TLR4+896A>G, andTLR9haplotypes showed that theTLR2haplotype combinations AG-TA and AG-TG confer risk (OR 3.4 (P= 0.01) and 1.6 (P= 0.03)), while theTLR9haplotype combination TG-TA protects againstC. trachomatisinfections (OR: 0.4,P= 0.004). Our study shows that bothTLR2andTLR9genes and SNP combinations do influence the clinical course ofChlamydiainfections.
