Highly-luminescent Eu,Sm,Mn-doped CaS up/ down conversion nano-particles: application to ultra-sensitive latent fingerprint detection and in vivo bioimaging
Highly-luminescent Eu,Sm,Mn-doped CaS up/ down conversion nano-particles: application to ultra-sensitive latent fingerprint detection and in vivo bioimaging
复制标题
高发光Eu、Sm、Mn掺杂CaS上/下转换纳米颗粒：在超灵敏潜指纹检测和体内生物成像中的应用
DOI：
10.1039/c7cc07790d
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Cai Qingyun
中科院分区：
文献类型：
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作者：
Wang Jikai;HeNi;ZhuYanli;An Zhengbin;Chen Ping;Grimes Craig A;Nie Zhou;Cai Qingyun
由于其独特的性质，稀土掺杂上转换发光（UCL）纳米材料具有相当大的科学意义。同时，基于完全不同的电子捕获（ET）机制的碱土硫化物材料表现出极高的UCL效率，是传统氟化物UCL纳米材料的数十倍。然而，其粒径大、易水解、难以实现均匀分散等阻碍了生物测定的应用。在此，我们使用反相微乳液技术合成了平均粒径约 30 nm 的超亮 Eu、Sm、Mn 掺杂 CaS 纳米粒子。 UCL量子产率高达近60%。用有机层对纳米颗粒进行改性使其能够稳定地分散在整个水溶液中，而不会显着损失荧光强度。我们展示了新型 UCL 材料在潜指纹检测、深层组织成像和体内生物成像中的应用。
Due to their unique properties, rare-earth doped upconversion luminescence (UCL) nanomaterials are of considerable scientific interest. Meanwhile, alkaline-earth sulfide materials based on a completely different electron trapping (ET) mechanism demonstrate extremely high UCL efficiencies, which are several dozens of times more than those of conventional fluoride UCL nanomaterials. However, the large particle size, easy hydrolysis, and difficulty in achieving uniform dispersion have precluded bioassay applications. Herein, we have synthesized super-bright Eu,Sm,Mn-doped CaS nanoparticles of ∼30 nm average particle size using a reverse microemulsion technique. The UCL quantum yield was up to nearly 60%. Modification of the nanoparticles with an organic layer allows their stable dispersion throughout aqueous solutions without significant loss of the fluorescence intensity. We demonstrate the application of the novel UCL materials to latent fingerprint detection, deep tissue imaging, and in vivo bioimaging.