A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA.
A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA.
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一种共生超分子方法设计具有抗 MSRA 抗菌特性的新型两亲物。
DOI：
10.1039/c8cc08485h
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Tyuleva SN
中科院分区：
文献类型：
--
作者：
Tyuleva SN
在此，我们确定超分子自缔合两亲物（SSAs）作为一类新的抗菌药物对耐甲氧西林金黄色葡萄球菌的活性。结构-活性关系已确定在固相，溶液和气相。最后，我们表明，当组合提供时，SSA对这些临床相关的微生物表现出更高的抗菌功效。
Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus. Structure–activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.