Raphe unit activity in freely moving cats: Effects of benzodiazepines
Raphe unit activity in freely moving cats: Effects of benzodiazepines
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自由活动的猫的中缝单位活动：苯二氮卓类药物的影响
DOI：
10.1016/0028-3908(82)90120-4
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发表时间：
1982
影响因子：
4.7
通讯作者：
Christopher J. Frederickson
中科院分区：
文献类型：
--
作者：
M. Trulson;D. W. Preussler;G. A. Howell;Christopher J. Frederickson
苯二氮卓类药物（利血平和地西泮）在自由活动的猫中缝背核中产生了剂量依赖性的降低含降钙素神经元的放电率。其范围为0.5和1.0 mg/kg（i. p.）剂量下无显著变化，在10 mg/kg剂量下，单位活性降低超过90%。苯二氮卓类药物对中缝单位的影响发生在注射后15-30分钟内，作用持续时间呈剂量依赖性，持续时间为1至6小时以上。显著降低中缝单位活动的苯二氮卓类药物剂量（即2.5-10 mg/kg）也会产生共济失调和EMG活动降低。这些数据表明，苯二氮卓诱导的中缝单位活动的抑制是密切相关的一般运动行为。在进食、梳理或捕食行为期间，在EMG活动的阶段性增加期间，中缝细胞单位活动仍然受到抑制，这表明苯二氮卓类药物对中缝细胞也有直接的抑制作用。目前的研究结果进行了讨论的背景下，焦虑的神经递质假说。
Benzodiazepines (chlordiazepoxide and diazepam) produced a dose-dependent decrease in the discharge rate of serotonin-containing neurons in the dorsal raphe nucleus of freely moving cats. This ranged from no significant change at doses of 0.5 and 1.0mg/kg (i.p.), to greater than 90% reductions in unit activity at 10 mg/kg. The effects of benzodiazepines on raphe units occurred within 15–30 min of injection and the duration of action was dose-dependent and lasted from 1 to more than 6 hr. Doses of benzodiazepines that significantly decreased raphe unit activity (i.e. 2.5–10 mg/kg) also produced ataxia and decreased EMG activity. These data suggest that benzodiazepine-induced suppression of raphe unit activity is closely related to general motor behavior. Raphe unit activity remained suppressed during phasic increases in EMG activity during eating, grooming, or predatory behavior, suggesting that benzodiazepines also have a direct inhibitory action on raphe cells. The present results are discussed in the context of the serotonergic hypothesis of anxiety.
肾上腺素能药物对自由活动猫中缝单位活性的影响。
影响因子：
5
作者：
Heym,J;Trulson,ME;Jacobs,BL
通讯作者：
Jacobs,BL