Skin manifestations of arsenicosis in two villages in Bangladesh
Skin manifestations of arsenicosis in two villages in Bangladesh
复制标题
DOI：
10.1046/j.1365-4362.2002.01668.x
复制
发表时间：
2002-12-01
影响因子：
3.6
通讯作者：
Ohtsuka, R
中科院分区：
文献类型：
--
作者：
Kadono, T;Inaoka, T;Ohtsuka, R
孟加拉国地下水中的砷污染影响到3500万人，但当地社区砷污染的普遍程度仍有待澄清。由于皮肤表现砷中毒的敏感标志物，我们检查了皮肤的成人和青少年在两个村庄，以阐明砷中毒的严重程度。方法561村民被随机选择的评价他们的皮肤。结果50%以上的村民有砷中毒的皮肤表现。脚掌角化是早期砷中毒最敏感的诊断指标。有趣的是，男性的皮肤表现比女性更严重。结论砷中毒的患病率较高，男性更易受到砷污染的危害。利用皮肤表现，特别是脚底角化病作为检测和评估砷中毒的有用标志，显然迫切需要评估孟加拉国人口中砷中毒的确切流行率和严重程度，以便采取措施治疗和控制这一问题。
Background Arsenic contamination in groundwater affects 35 million people in Bangladesh, but the prevalence of arsenic contamination in local communities remains to be clarified. As skin manifestations are sensitive markers of arsenicosis, we examined the skin of adults and adolescents in two villages to elucidate the severity of arsenicosis.Methods Five hundred and sixty-one villagers were randomly selected for the evaluation of their skin. Three indicators, i.e. keratosis on the soles, keratosis on the palms, and melanosis and hypopigmentation on the trunk, were quantified for analysis.Results More than 50% of the villagers showed some skin manifestations due to arsenicosis. Keratosis on the soles was the most sensitive marker for the detection of arsenicosis at an early stage. Interestingly, the skin manifestations were more severe in males than in females. There was no correlation between the age and the severity of skin manifestations.Conclusions The prevalence of arsenicosis was quite high and males were more vulnerable to arsenic contamination. Using skin manifestations, especially keratosis on the soles, as useful markers to detect and evaluate arsenicosis, it is clear that there is an urgent need to assess the exact prevalence and severity of arsenicosis in the population of Bangladesh in order to take measures to treat and control this problem.