Early Visual Symptom Patterns in Inherited Retinal Dystrophies
Early Visual Symptom Patterns in Inherited Retinal Dystrophies
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DOI：
10.1159/000330381
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发表时间：
2011-01-01
期刊：
影响因子：
2.6
通讯作者：
Zrenner, Eberhart
中科院分区：
文献类型：
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作者：
Prokofyeva, Elena;Troeger, Eric;Zrenner, Eberhart
本回顾性研究比较了遗传性视网膜营养不良（IRD）的初始视觉症状模式，基于2005年至2008年在图宾根大学眼科医院诊断为各种IRD的544例患者的记录。记录首次出现症状时的年龄，并分析以下临床数据：视力（VA）、夜间视力障碍、畏光症、视野缺损发作、最佳矫正VA和视野缺损类型。视觉症状发作时的中位年龄定义为第25和第75个年龄段，并在15种IRD类型中进行比较。确定了视网膜色素变性和视锥-视杆细胞营养不良VA变化的主要趋势。本研究首次将联合收割机病史和临床数据分析结合在如此广泛的IRD中。这表明，IRD的初始症状模式可以为早期鉴别诊断和将IRD患者纳入临床试验提供额外的线索。版权所有（C）2011 S. Karger AG，巴塞尔
The present retrospective study compared initial visual symptom patterns in inherited retinal dystrophies (IRD) on the basis of records of 544 patients diagnosed with a wide variety of IRD at the Tuebingen University Eye Hospital from 2005 to 2008. Age at first onset of symptoms was noted, and the following clinical data were analyzed: visual acuity (VA), night vision disturbances, photophobia, onset of visual field defects, best corrected VA, and types of visual field defects. Median age at visual symptom onset was defined with 25th and 75th percentiles and compared in 15 IRD types. The main trends in VA changes in retinitis pigmentosa and cone-rod dystrophies were identified. This study was the first to combine disease history and clinical data analysis in such a wide variety of IRD. It showed that patterns of initial symptoms in IRD can provide extra clues for early differential diagnosis and inclusion of IRD patients in clinical trials. Copyright (C) 2011 S. Karger AG, Basel