The Age of Olfactory Bulb Neurons in Humans
The Age of Olfactory Bulb Neurons in Humans
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DOI：
10.1016/j.neuron.2012.03.030
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发表时间：
2012-05-24
期刊：
影响因子：
16.2
通讯作者：
Frisen, Jonas
中科院分区：
文献类型：
--
作者：
Bergmann, Olaf;Liebl, Jakob;Frisen, Jonas
嗅球神经元的持续更新与嗅觉的几个关键方面有关。出生后，迁移到人类嗅球的成神经细胞数量急剧下降，并且尚不清楚后期阶段的少量成神经细胞在多大程度上为嗅球提供了新的神经元。我们通过测量基因组DNA中核弹试验衍生的C-14水平来评估人类嗅球神经元的年龄。我们报告说，C-14浓度对应于个人出生时的大气水平，建立有非常有限的，如果有的话，在人类嗅球出生后的神经发生。这确定了人类大脑与其他哺乳动物相比在可塑性方面的根本差异。
Continuous turnover of neurons in the olfactory bulb is implicated in several key aspects of olfaction. There is a dramatic decline postnatally in the number of migratory neuroblasts en route to the olfactory bulb in humans, and it has been unclear to what extent the small number of neuroblasts at later stages contributes new neurons to the olfactory bulb. We have assessed the age of olfactory bulb neurons in humans by measuring the levels of nuclear bomb test-derived C-14 in genomic DNA. We report that C-14 concentrations correspond to the atmospheric levels at the time of birth of the individuals, establishing that there is very limited, if any, postnatal neurogenesis in the human olfactory bulb. This identifies a fundamental difference in the plasticity of the human brain compared to other mammals.