A multi-scale computational method applied to the quantitative evaluation of the left ventricular function
A multi-scale computational method applied to the quantitative evaluation of the left ventricular function
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DOI：
10.1016/j.compbiomed.2006.06.011
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发表时间：
2007-05-01
影响因子：
7.7
通讯作者：
Liu, Hao
中科院分区：
文献类型：
--
作者：
Liang, Fuyou;Taniguchi, Hisashi;Liu, Hao
本文提出了一种多尺度计算方法，将心血管系统（CVS）的集总参数模型与三维左心室（LV）血流动力学求解器相结合，用于定量评价LV功能。参数模型允许在正常和各种病理条件下以闭环方式合理预测心脏变量。在参数模型预测结果的基础上，3D血流动力学计算进一步提供了对详细的心室内流动模式的定量见解。通过一系列的计算，证明了左心室形状和大小的病理变化对左心室泵送性能有显著的影响。(c)2006爱思唯尔有限公司版权所有。
A multi-scale computational method, which combines a lumped parameter model of the cardiovascular system (CVS) with a three-dimensional (3D) left ventricle (LV) hemodynamic solver, is developed for quantitatively evaluating the LV function. The parameter model allows reasonable predictions of the cardiac variables in a closed-loop manner under both normal and various pathological conditions. On the basis of the parameter-model-predicted results, 3D hemodynamic computations further provide quantitative insights into the detailed intraventricular flow patterns. Based on a series of computations, it is demonstrated that the pathological change in the shape and size of the LV has a significant effect on the LV pumping performance. (c) 2006 Elsevier Ltd. All rights reserved.