Treatment for Leigh syndrome by monitoring dichloroacetate concentration
Treatment for Leigh syndrome by monitoring dichloroacetate concentration
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DOI：
10.1111/j.1442-200x.2009.02815.x
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发表时间：
2009-04-01
影响因子：
1.4
通讯作者：
Sugimoto, Tohru
中科院分区：
文献类型：
--
作者：
Katsumi, Yoshiki;Morimoto, Masafumi;Sugimoto, Tohru
本文介绍了一个病例研究的男孩与利综合征（LS）或亚急性坏死性脑病。它揭示了给病人服用二氯醋酸钠（DCA）25- 50 mg/kg/天，持续几个月，并在入院第五天服用硫胺素10 mg/kg/天。它揭示了在患者中观察到的疾病症状，包括面无表情和肌肉无力。它引用了通过磁共振成像和血液学实验室检查的结果。
The article presents a case study of a boy with Leigh syndrome (LS) or subacute nectorizing encephalopathy. It reveals the administration of 25-50mg/kg per day of sodium dichloroacetate (DCA) to the patient for a few months and of 10mg/kg per day thiamine on the fifth day of admission. It reveals the symptoms of the disease observed in the patients including blank face and muscle weakness. It cites the results of the examinations through magnetic resonance imaging and hematologic laboratory.